{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:48:48Z","timestamp":1792633728138,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T00:00:00Z","timestamp":1691712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Stimulant laxatives may cause electrolyte abnormalities, dehydration, and abdominal pain; their long\u2010term use can lead to tolerance and subsequent refractory constipation. We investigated the effectiveness, safety, and quality of life after switching from stimulant laxatives to lubiprostone in elderly patients with chronic constipation (CC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This multicenter, interventional, open\u2010label, single\u2010arm, before\u2010and\u2010after comparison study enrolled 99 Japanese patients aged 65\u201390\u2009years with CC who took stimulant laxatives for \u22652\u2009weeks prior to switching to lubiprostone monotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean\u2009\u00b1\u2009SD spontaneous defecations at Week 1 of 7.8\u2009\u00b1\u20096.2 times\/week was not significantly different from that at baseline (8.3\u2009\u00b1\u20094.7). Spontaneous defecations were significantly reduced at Weeks 2 (\u22121.5\u2009\u00b1\u20094.0, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and 4 (\u22121.5\u2009\u00b1\u20093.7, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The Bristol Stool Form Scale score did not change from baseline (4.7\u2009\u00b1\u20090.9) at Weeks 1 (4.5\u2009\u00b1\u20091.3) or 4 (4.3\u2009\u00b1\u20091.3), but it did at Week 2 (4.3\u2009\u00b1\u20091.5, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The Patient Assessment of Constipation Quality of Life questionnaire score increased (0.36\u2009\u00b1\u20090.07, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) after 28\u2009days. Nausea was the only symptom that worsened from baseline and was the most frequently reported adverse drug reaction (15.2%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Switching to lubiprostone monotherapy for CC was not associated with significant concerns in short\u2010term spontaneous defecation frequency and safety, but it might affect the efficacy and patient quality of life over 2\u2009weeks. Careful treatment strategies facilitating gradual switching to lubiprostone monotherapy may be needed in patients using stimulant laxatives.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.12956","type":"journal-article","created":{"date-parts":[[2023,8,12]],"date-time":"2023-08-12T04:41:06Z","timestamp":1691815266000},"page":"610-617","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effectiveness and safety of lubiprostone after switching from stimulant laxatives in elderly patients with chronic constipation"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9534-4652","authenticated-orcid":false,"given":"Masaki","family":"Maruyama","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Kashiwazaki General Hospital and Medical Center  Kashiwazaki Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suguru","family":"Miida","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kashiwazaki General Hospital and Medical Center  Kashiwazaki Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Sato","sequence":"additional","affiliation":[{"name":"Sato Clinic  Kashiwazaki Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takazumi","family":"Kimura","sequence":"additional","affiliation":[{"name":"Kimura Internal Medicine Clinic  Yokohama Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azuma","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Kameda Daiichi Hospital  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Surgery Watanabe Hospital  Matsuyama Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Nishizawa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Minamisanriku Hospital  Motoyoshi\u2010gun Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyohei","family":"Horikawa","sequence":"additional","affiliation":[{"name":"Wakamatsuen Health Care Facility for the Elderly  Okinawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Kajiwara","sequence":"additional","affiliation":[{"name":"Lotus Care Center, Health Care Facility for the Elderly  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8086-1366","authenticated-orcid":false,"given":"Yusuke","family":"Karasawa","sequence":"additional","affiliation":[{"name":"Medical Affairs, Viatris Pharmaceuticals Japan Inc.  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Hasebe","sequence":"additional","affiliation":[{"name":"Medical Affairs, Viatris Pharmaceuticals Japan Inc.  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4245-2657","authenticated-orcid":false,"given":"Kazutaka","family":"Nozawa","sequence":"additional","affiliation":[{"name":"Medical Affairs, Viatris Pharmaceuticals Japan Inc.  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5439-635X","authenticated-orcid":false,"given":"Shuji","family":"Terai","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology &amp; Hepatology, Graduate School of Medical and Dental Sciences Niigata University  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,11]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Evidence\u2010Based Clinical Practice Guidelines for Chronic Constipation, 2017","author":"Research Society for the Diagnosis and Treatment of Chronic Constipation","year":"2017"},{"key":"e_1_2_9_3_1","unstructured":"Ministry of Health Labour and Welfare.Overview of the 2016 comprehensive survey of living conditions. Accessed 11 Oct 2022. 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