{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T18:05:09Z","timestamp":1781201109993,"version":"3.54.1"},"reference-count":68,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T00:00:00Z","timestamp":1693872000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>There is an intimate relationship between oxidative stress and inflammation. <jats:italic>Helicobacter pylori (H. pylori)<\/jats:italic> infection leads to gastritis in almost all the hosts. So, we hypothesize that gastritis in <jats:italic>H. pylori<\/jats:italic> infection may be described as the accumulation of continuous oxidative damage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study was conducted from October 2020 to October 2021 at three reference health facilities in Cameroon<jats:italic>.<\/jats:italic> A total of 266 participants (131 males and 135 females) ranging from 15 to 88\u2009years old with 48.28\u2009\u00b1\u200917.29\u2009years as mean age were enrolled. Each participant gave a written informed consent and ethical committees approved the protocol. Biopsies samples were collected for <jats:italic>H. pylori<\/jats:italic> detection using histological examination and rapid urease test. Malondialdehyde (MDA) and glutathione (GSH) content, and catalase (CAT) and superoxide dismutase (SOD) activities were evaluated in serum as biomarkers of oxidative stress.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>Helicobacter pylori<\/jats:italic> was detected in 71.80% of our sample population. Low income level was associated with higher GSH level (<jats:italic>P<\/jats:italic>\u2009=\u20090.0249) and having family history of gastric cancer to higher SOD activity (<jats:italic>P<\/jats:italic>\u2009=\u20090.0156). A significant higher MDA content (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001) and SOD activity (<jats:italic>P<\/jats:italic>\u2009=\u20090.0235) was recorded among infected individuals compared with noninfected ones. A significantly higher MDA content and SOD activity was recorded among smokers (<jats:italic>P<\/jats:italic>\u2009=\u20090.0461) and participants older than 50\u2009years old (<jats:italic>P<\/jats:italic>\u2009=\u20090.0491) with <jats:italic>H. pylori<\/jats:italic> positivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings showed that <jats:italic>H. pylori<\/jats:italic> infection is associated with overproduction of reactive oxygen species and oxidative stress. The presence of this pathogen in elderly individuals or in smokers increased their risk for oxidative stress.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.12958","type":"journal-article","created":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T10:19:34Z","timestamp":1693909174000},"page":"618-628","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["<scp><i>Helicobacter pylori<\/i><\/scp> infection\u2014A risk factor for lipid peroxidation and superoxide dismutase over\u2010activity: A cross\u2010sectional study among patients with dyspepsia in Cameroon"],"prefix":"10.1002","volume":"7","author":[{"given":"Ghislaine Florice","family":"Faujo Nintewoue","sequence":"first","affiliation":[{"name":"Microbiology and Pharmacology Laboratory, Department of Biochemistry, Faculty of Science University of Dschang  Dschang Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel Danny","family":"Tali Nguefak","sequence":"additional","affiliation":[{"name":"Microbiology and Pharmacology Laboratory, Department of Biochemistry, Faculty of Science University of Dschang  Dschang Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghislaine","family":"Ngatcha","sequence":"additional","affiliation":[{"name":"Regional Hospital Bafoussam  Bafoussam Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sartre Michele","family":"Tagni","sequence":"additional","affiliation":[{"name":"Centre M\u00e9dicale la Cath\u00e9drale  Yaound\u00e9 Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Talla","sequence":"additional","affiliation":[{"name":"General Hospital Yaound\u00e9  Yaound\u00e9 Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole Marlyse","family":"Menzy Moungo\u2010Ndjole","sequence":"additional","affiliation":[{"name":"General Hospital Yaound\u00e9  Yaound\u00e9 Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6447-1413","authenticated-orcid":false,"given":"Laure Brigitte","family":"Kouitcheu Mabeku","sequence":"additional","affiliation":[{"name":"Microbiology and Pharmacology Laboratory, Department of Biochemistry, Faculty of Science University of Dschang  Dschang Cameroon"},{"name":"Medical Microbiology Laboratory, Department of Microbiology, Faculty of Science University of Yaound\u00e9 I  Yaound\u00e9 Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2006.8.1865"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/WOX.0b013e3182439613"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2015.10.001"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2010.10.016"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajme.2017.09.001"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.advms.2017.05.005"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.54.3.176"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22158010"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-013-1423-y"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-017-0678-6"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/6024975"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)90938-D"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199110173251603"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.5152\/tjg.2017.16557"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i30.10348"},{"key":"e_1_2_10_17_1","first-page":"132","article-title":"Prevalence of Helicobacter pylori infection among adult dyspeptic patients in Ethiopia","volume":"32","author":"Asrat D","year":"2004","journal-title":"Ann. 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