{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T03:29:59Z","timestamp":1785036599211,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T00:00:00Z","timestamp":1695340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To investigate the diagnostic accuracy of fecal calprotectin (FC) for inflammatory bowel disease (IBD) and organic gastrointestinal disease (OGID) in primary care. To examine the association with demographic factors, symptoms and concomitant medical therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis of data on all semiquantitative FC tests from individuals \u226518\u2009years conducted in primary care in \u00d6sterg\u00f6tland County in 2010. A 5\u2010year follow\u2010up with inclusion of new gastrointestinal diagnoses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1293 eligible patients were included. IBD was found in 8.8% and other OGID in 30.8% of patients with positive FC. Positive FC was associated with diarrhea, age &gt;60\u2009years, duration &lt;3\u2009months, use of nonsteroidal anti\u2010inflammatory drug (NSAID), and proton pump inhibitor (PPI). Predictors of IBD were positive FC, diarrhea, rectal bleeding, and male sex; predictors of OGID positive FC, age &gt;35\u2009years, abnormal clinical findings, and duration &lt;3\u2009months. FC yielded the highest sensitivity and negative predictive value compared with demographic factors, symptoms, and duration. Use of NSAID and PPI showed a marginal increase in the sensitivity, positive predictive value, and decrease in the specificity of FC. Within 5\u2009years, 4.0% had a new gastrointestinal diagnosis among patients with positive FC (0.6% IBD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>FC reliably rules out IBD and contradicts the presence of other OGID in primary care patients. Positive FC test together with other predictors, such as diarrhea, rectal bleeding, short duration, or age &gt;35\u2009years, should encourage a prioritized investigation. Use of NSAID, PPI, and ASA may affect the diagnostic accuracy of FC for IBD and OGID.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.12972","type":"journal-article","created":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T10:16:12Z","timestamp":1695377772000},"page":"708-716","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Diagnostic value of fecal calprotectin in primary care patients with gastrointestinal symptoms: A retrospective Swedish cohort study"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2306-4966","authenticated-orcid":false,"given":"Zlatica","family":"Rendek","sequence":"first","affiliation":[{"name":"Department of Biomedical and Clinical Sciences Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6688-3860","authenticated-orcid":false,"given":"Magnus","family":"Falk","sequence":"additional","affiliation":[{"name":"Department of Health, Medicine and Caring Sciences Link\u00f6ping University  Link\u00f6ping Sweden"},{"name":"Primary Health Care Centre K\u00e4rna Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Grodzinsky","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7614-739X","authenticated-orcid":false,"given":"Stergios","family":"Kechagias","sequence":"additional","affiliation":[{"name":"Department of Health, Medicine and Caring Sciences Link\u00f6ping University  Link\u00f6ping Sweden"},{"name":"Division of Diagnostics and Specialist Medicine, Department of Health, Medicine and Caring Sciences Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6352-5419","authenticated-orcid":false,"given":"Henrik","family":"Hjortswang","sequence":"additional","affiliation":[{"name":"Department of Health, Medicine and Caring Sciences Link\u00f6ping University  Link\u00f6ping Sweden"},{"name":"Department of Gastroenterology and Hepatology in Link\u00f6ping, and Department of Health, Medicine, and Caring Sciences Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2017.e00328"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.46.1.78"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/flgastro-2011-100011"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2011.177980"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14563"},{"key":"e_1_2_8_7_1","first-page":"41","article-title":"Clinical utility and diagnostic accuracy of faecal calprotectin for IBD at first presentation to gastroenterology services in adults aged 16\u201350\u2009years","volume":"9","author":"Kennedy NA","year":"2015","journal-title":"J. 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