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In the past, screening of fecal donors required surveillance of personal behavior, medical history, and diseases that could be transmitted by the blood or fecal\u2013oral route. In addition, the exclusion of multidrug\u2010resistant organisms (MDROs) has been recommended since 2018. This task has become more complicated in the era of the coronavirus disease\u20102019 (COVID\u201019) pandemic. To prevent fecal transmission of severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102), it is crucial to commence screening for SARS\u2010CoV\u20102, alongside other traditional tests. Our aim was to investigate whether hidden carriers of SARS\u2010CoV\u20102 were enrolled for stool donation, and the status of the presence or incidence of MDRO during fecal donation in Taiwan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fecal products collected from March 2019 to December 2022 were tested for MDRO and nucleic acid amplification tests for SARS\u2010CoV\u20102 using the pooling method. The period of fecal product collection crossed the time before and during the COVID pandemic in Taiwan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 151 fecal samples were collected. The fecal products were tested using polymerase chain reaction (PCR) to detect SARS\u2010CoV\u20102. The results were negative for all stocks. This was similar to the results of MDRO testing. The safety of FMT products has been guaranteed during the pandemic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our FMT center produced MDRO\u2010free and COVID\u201019\u2010free products before and during the COVID\u201019 outbreak in Taiwan. Our protocol was effective for ensuring the safety of FMT products.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.12979","type":"journal-article","created":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T07:27:27Z","timestamp":1697786847000},"page":"765-771","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Assuring safety of fecal microbiota transplantation in the <scp>COVID<\/scp>\u201019 era: A single\u2010center experience"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2810-9193","authenticated-orcid":false,"given":"Tien\u2010En","family":"Chang","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Endoscopic Center for Diagnosis and Therapy Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"School of Medicine, College of Medicine, National Yang Ming Chiao Tung University  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