{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T11:02:12Z","timestamp":1781521332897,"version":"3.54.1"},"reference-count":37,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T00:00:00Z","timestamp":1699574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p><jats:italic>Helicobacter pylori<\/jats:italic> eradication therapy effectively improves the abdominal symptoms and bowel habits of patients. Patients in whom dyspepsia is under control by 6 to 12\u2009months after successful <jats:italic>H. pylori<\/jats:italic> eradication are defined as having <jats:italic>H. pylori<\/jats:italic>\u2010associated dyspepsia, and patients with dyspepsia that is refractory to successful eradication are defined as having functional dyspepsia. Here, we aimed to investigate the association between <jats:italic>H. pylori<\/jats:italic> eradication and improvement of dyspepsia in the short and long term after eradication therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Dyspeptic symptoms before treatment and at 2 and 12\u2009months after eradication were evaluated using the Gastrointestinal Symptom Rating Scale (GSRS) in 282 <jats:italic>H. pylori\u2010<\/jats:italic>positive Japanese patients who underwent eradication therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the Japanese <jats:italic>H. pylori\u2010<\/jats:italic>positive patients, 48.2% (136\/282) had upper abdominal symptoms. Eradication improved dyspepsia in 34.5% (47\/136) of the patients at 2\u2009months post eradication, which continued to be under control up to 12\u2009months. A significant decrease at 2 and 12\u2009months after eradication, compared with before eradication, was observed in total GSRS (from 25.7\u2009\u00b1\u200910.4 [before eradication, <jats:italic>n<\/jats:italic>\u2009=\u2009249] to 23.3\u2009\u00b1\u20097.2 [after 2\u2009months, <jats:italic>n<\/jats:italic>\u2009=\u2009249] and 24.8\u2009\u00b1\u20097.8 [after 12\u2009months, <jats:italic>n<\/jats:italic>\u2009=\u200981]; <jats:italic>P<\/jats:italic>\u2009=\u20090.014 and 0.321, respectively), gastric pain score (from 4.1\u2009\u00b1\u20091.9 to 3.7\u2009\u00b1\u20091.3 and 3.7\u2009\u00b1\u20091.2; <jats:italic>P<\/jats:italic>\u2009=\u20090.025 and 0.047), and constipation score (from 5.9\u2009\u00b1\u20093.1 to 5.2\u2009\u00b1\u20092.3 and 5.9\u2009\u00b1\u20093.0; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.021 and 0.862).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>H. pylori<\/jats:italic>\u2010positive dyspepsia patients should be recommended to undergo <jats:italic>H. pylori<\/jats:italic> eradication to alleviate dyspepsia\u2010associated symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.12986","type":"journal-article","created":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T06:04:52Z","timestamp":1699682692000},"page":"855-862","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Improvement of dyspeptic symptoms after <i>Helicobacter pylori<\/i> eradication therapy in Japanese patients"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1201-8312","authenticated-orcid":false,"given":"Eri","family":"Iwata","sequence":"first","affiliation":[{"name":"Department of Gastroenterological Endoscopy Tokyo Medical University Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9194-7392","authenticated-orcid":false,"given":"Mitsushige","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Endoscopy Tokyo Medical University Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Murata","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology National Hospital Organization Kyoto Medical Center  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Morino","sequence":"additional","affiliation":[{"name":"Tokyo University of Pharmacy and Life Sciences  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshika","family":"Akimoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Endoscopy Tokyo Medical University Hospital  Tokyo 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