{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:30:01Z","timestamp":1773009001302,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:00:00Z","timestamp":1706832000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Combining proton pump inhibitors (PPIs) with prokinetics can provide synergistic action in patients with gastroesophageal reflux disease (GERD) and overlapping dyspepsia, but data regarding this is lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This single\u2010center, prospective study evaluated the efficacy and safety of 6\u2010week treatment with fixed\u2010drug combination (FDC) of pantoprazole (PPI) and itopride (prokinetic) in 50 patients with \u22653 month history of GERD and overlapping dyspepsia refractory to pantoprazole. Efficacy was assessed as reduction in GERD symptom assessment scale (GSAS) distress score for 15 symptoms from baseline to week 6. Adverse events (AEs) were monitored up to week 6.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Although heartburn was the most common symptom at week 6 (26.8%), its frequency significantly decreased from baseline (84.0%; <jats:italic>P<\/jats:italic>\u2009&lt;0.01). A similar trend was observed for other symptoms: pressure\/discomfort inside chest (19.5%), belching (14.6%), regurgitation (12.2%), bloating (9.8%), flatulence (9.8%), early satiety (7.3%), acidic\/sour taste in mouth (7.3%), nausea (7.3%), frequent gurgling in stomach\/belly (4.9%), and pressure\/lump in throat (2.4%). Mean distress scores of all symptoms markedly decreased at week 6. Three AEs (<jats:italic>n<\/jats:italic>\u2009=\u20092) of moderate intensity were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The FDC of pantoprazole and itopride showed favorable efficacy and safety in patients with GERD and overlapping dyspepsia refractory to pantoprazole monotherapy. Nevertheless, further studies are warranted.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.12988","type":"journal-article","created":{"date-parts":[[2024,2,3]],"date-time":"2024-02-03T06:06:35Z","timestamp":1706940395000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy and safety of pantoprazole and itopride in patients with overlap of gastroesophageal reflux disease and dyspepsia: A prospective, open\u2010label, single\u2010arm pilot study"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7562-8060","authenticated-orcid":false,"given":"Sundeep","family":"Lakhtakia","sequence":"first","affiliation":[{"name":"Department of Medical Gastroenterology AIG Hospitals  Hyderabad India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aniruddha P","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Medical Gastroenterology AIG Hospitals  Hyderabad India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neeraj","family":"Singla","sequence":"additional","affiliation":[{"name":"Department of Medical Gastroenterology AIG Hospitals  Hyderabad India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sana F","family":"Memon","sequence":"additional","affiliation":[{"name":"AIG Hospitals  Hyderabad India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duvvur N","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Medical Gastroenterology AIG Hospitals  Hyderabad India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00630.x"},{"key":"e_1_2_7_3_1","first-page":"222","article-title":"Dyspepsia and gastroesophageal reflux disease (GERD): Is there any correlation?","volume":"41","author":"Simadibrata M","year":"2009","journal-title":"Acta Med. Indones."},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314722"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000485408"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12664-019-00979-y"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12664-010-0065-5"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12664-010-0066-4"},{"key":"e_1_2_7_9_1","first-page":"2","article-title":"Evaluation of safety and efficacy of pantoprazole and domperidone combination in patients with gastroesophageal reflux disease","volume":"4","author":"Singhal S","year":"2006","journal-title":"Internet J, Gastroenterol."},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i39.6529"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-311715"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-008-0052-5"},{"key":"e_1_2_7_13_1","first-page":"75","article-title":"Frequency scale for the symptoms of GERD score for gastroesophageal reflux disease in Koja hospital","volume":"11","author":"Ndraha S","year":"2010","journal-title":"Indones. J. Gastroenterol. Hepatol. Dig. Endosc."},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2007.05218.x"},{"key":"e_1_2_7_15_1","first-page":"233","article-title":"Combination of PPI with a prokinetic drug in gastroesophageal reflux disease","volume":"43","author":"Ndraha S","year":"2011","journal-title":"Acta Med. Indones."},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000165351"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2050.2004.00424.x"},{"key":"e_1_2_7_18_1","first-page":"1953","article-title":"A comparative prospective study to assess the clinical efficacy and safety of pantoprazole monotherapy versus pantoprazole and itopride dual therapy in patients with gastroesophageal reflux disease in a tertiary care hospital","volume":"5","author":"Pradeep BT","year":"2016","journal-title":"Int. J. Basic Clin. Pharmacol."},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-009-0173-0"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015815102175"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010660425522"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm20161"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i48.7371"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i27.4210"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(18)30751-0"},{"key":"e_1_2_7_26_1","first-page":"626","article-title":"Comparative evaluation of the efficacy and tolerability of itopride hydrochloride and domperidone in patients with non\u2010ulcer dyspepsia","volume":"52","author":"Sawant P","year":"2004","journal-title":"J. Assoc. Physicians India"},{"key":"e_1_2_7_27_1","first-page":"387","article-title":"Efficacy and tolerability of itopride hydrochloride in patients with non\u2010ulcer dyspepsia","volume":"101","author":"Shenoy KT","year":"2003","journal-title":"J. Indian Med. Assoc."},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.4292\/wjgpt.v8.i1.74"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.132449"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052639"},{"key":"e_1_2_7_31_1","first-page":"814","article-title":"Itopride and pantoprazole outcomes in diabetic gastroparesis trial (IPOD trial)","volume":"106","author":"Venkatesh V","year":"2008","journal-title":"J. Indian Med. Assoc."},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2007.01058.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15191"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000543"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03256924"}],"container-title":["JGH Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgh3.12988","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T10:16:27Z","timestamp":1709115387000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jgh3.12988"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1002\/jgh3.12988"],"URL":"https:\/\/doi.org\/10.1002\/jgh3.12988","archive":["Portico"],"relation":{},"ISSN":["2397-9070","2397-9070"],"issn-type":[{"value":"2397-9070","type":"print"},{"value":"2397-9070","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"2023-03-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12988"}}