{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:22:31Z","timestamp":1747149751264,"version":"3.40.5"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009717","name":"Eastern Health Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009717","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008897","name":"Janssen Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Capsule endoscopy allows the direct visualization of the small bowel. We examined the diagnostic utility of a new modality, namely panenteric Crohn's capsule endoscopy (CE), in detecting active small\u2010bowel Crohn's disease (CD) in those with normal magnetic resonance enterography (MRE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively recruited patients with a diagnosis of CD or suspected small\u2010bowel CD in whom the MRE was normal. Inclusion criteria included abdominal symptoms and abnormal serum or fecal biomarkers. The primary outcome was the detection of active small\u2010bowel CD (measured through the Lewis score [LS]). Secondary outcomes included change in Montreal classification for those with a pre\u2010existing CD diagnosis, change in medical therapy, clinical activity, and biomarkers at baseline and 6\u2009months, and quality\u2010of\u2010life measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 22 patients with a diagnosis of CD or suspected new diagnosis were recruited, with CE complete to the caecum in 21 and 18\/21 (86%) showing evidence of active small\u2010bowel CD (LS\u2009&gt;\u2009135). Of the patients with a pre\u2010existing diagnosis of CD, 9\/11 (82%) had a change in Montreal classification. At 6\u2009months following CE, 17\/18 (94%) had clinician\u2010directed change in therapy. This correlated with an improvement in the quality of life (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05 as per the Short Inflammatory Bowel Disease Questionnaire), a reduction in the Harvey Bradshaw index (median: 7\u20134, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and favorable CRP and albumin response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Crohn's CE is a useful diagnostic test for assessing active small\u2010bowel CD when imaging is normal but clinical suspicion is high. Crohn's CE should be integrated into the diagnostic algorithm for small\u2010bowel CD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.13013","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:32:00Z","timestamp":1701131520000},"page":"966-973","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Utility of panenteric capsule endoscopy for the detection of small\u2010bowel Crohn's disease in patients with a normal magnetic resonance enterography: A prospective observational pilot study"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2913-8225","authenticated-orcid":false,"given":"Anuj","family":"Bohra","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Box Hill Hospital  Box Hill Victoria Australia"},{"name":"Department of Gastroenterology Northern Hospital  Epping Victoria Australia"},{"name":"Eastern Health Clinical School Monash University  Box Hill Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Northern Hospital  Epping Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9668-0316","authenticated-orcid":false,"given":"Jonathan P","family":"Segal","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Royal Melbourne Hospital  Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5026-9014","authenticated-orcid":false,"given":"Abhinav","family":"Vasudevan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Box Hill Hospital  Box Hill Victoria Australia"},{"name":"Eastern Health Clinical School Monash University  Box Hill Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3662-6307","authenticated-orcid":false,"given":"Daniel R","family":"Van Langenberg","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Box Hill Hospital  Box Hill Victoria Australia"},{"name":"Eastern Health Clinical School Monash University  Box Hill Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3476-0422","authenticated-orcid":false,"given":"Olga","family":"Niewiadomski","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Box Hill Hospital  Box Hill Victoria Australia"},{"name":"Eastern Health Clinical School Monash University  Box Hill Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2022.138"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32448-0"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.07.062"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.579"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21417"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/17562848221078456"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/gidisord4040024"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13061061"},{"key":"e_1_2_9_10_1","first-page":"1408","article-title":"The utility of faecal calprotectin, lactoferrin and other faecal biomarkers in discriminating endoscopic activity in Crohn's disease: a systematic review and meta\u2010analysis","volume":"11","author":"Bohra A","year":"2023","journal-title":"Biomedicine"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.04.040"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/529136"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.5217\/ir.2016.14.3.211"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12102533"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.04.008"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/crocol\/otaa046"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.16007"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgast-2019-000365"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ueg2.12307"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-199304050-00006"},{"key":"e_1_2_9_21_1","first-page":"1571","article-title":"The Short Inflammatory Bowel Disease Questionnaire: a quality of life instrument for community physicians managing inflammatory bowel disease. 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