{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:57:12Z","timestamp":1753869432747,"version":"3.41.2"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T00:00:00Z","timestamp":1707955200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p><jats:italic>Helicobacter pylori<\/jats:italic> (Hp) infection is a real public health problem in the Congo. We aimed study the histomolecular profile of Hp strains circulating in Brazzaville, Congo, in order to contribute to the improvement of Hp\u2010infected patients in the country.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was an analytical\u2010transversal study carried out from January to November 2020 (i.e. a study period of 11\u2009months) in the endoscopy centers of Brazzaville as well as the molecular biology and anatomopathology laboratories of Pointe\u2010Noire and Oyo. It involved 100 symptomatic patients over the age of 18 referred for upper GI endoscopy. These patients underwent gastric biopsies for histopathological analysis according to the Sydney classification and molecular analysis using the real\u2010time polymerase chain reaction (PCR) technique. The frequency of Hp infection was determined using real\u2010time PCR. PCR was also used to identify the Hp strains and assess their tropism in the gastric mucosa. Digestive symptoms, endoscopic lesions, and histopathological lesions associated with HP infection were studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence of Hp infection was 91%, with a female predominance of 52.75% and an average age of 46.32\u2009years. Endoscopy revealed normal mucosa (56.14%), ulcerated lesions (12.28%), and gastritis (22.81%) in infected patients. Histopathologically, the lesions were chronic atrophic gastritis (91%), with inflammatory activity (16.46%), intestinal metaplasia (16.46%), and adenocarcinoma (3.3%). Cag A strains were present in 85.71% of cases and had no preferential tropism in the gastric mucosa. Strains carrying the Cag A gene were present in severe and serious endoscopic and histopathological lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prevalence of Hp infection is 91% in the Brazzaville population. Cag A strains circulate in high proportions and are implicated in the occurrence of severe lesions of the gastric mucosa.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.13035","type":"journal-article","created":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T07:29:10Z","timestamp":1708068550000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Histomolecular profile of <i>Helicobacter pylori<\/i> strains circulating in Brazzaville (Congo)"],"prefix":"10.1002","volume":"8","author":[{"given":"Bienvenu H","family":"Atipo\u2010Ibara","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences Marien Ngouabi University  Brazzaville Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anicet","family":"Boumba","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Marien Ngouabi University  Brazzaville Congo"},{"name":"Hugues Dieudonn\u00e9 Loemba Molecular Biology Laboratory  Pointe\u2010Noire Congo"},{"name":"Pointe\u2010Noire Research Zone Institut National de la Recherche en Sciences de la Sant\u00e9 (IRSSA)  Pointe\u2010Noire Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atipo","family":"Ibara Ollandzobo Ikobo","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Marien Ngouabi University  Brazzaville Congo"},{"name":"Gastroenterology and Internal Medicine Department Brazzaville University Hospital  Brazzaville Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnaud","family":"Mongo\u2010Onkouo","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Marien Ngouabi University  Brazzaville Congo"},{"name":"Gastroenterology and Internal Medicine Department Brazzaville University Hospital  Brazzaville Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jile F","family":"Mimiesse Mounamou","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Marien Ngouabi University  Brazzaville Congo"},{"name":"Gastroenterology and Internal Medicine Department Brazzaville University Hospital  Brazzaville Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ngala A","family":"Itoua\u2010Ngaporo","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Marien Ngouabi University  Brazzaville Congo"},{"name":"Gastroenterology and Internal Medicine Department Brazzaville University Hospital  Brazzaville Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donatien","family":"Moukassa","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Marien Ngouabi University  Brazzaville Congo"},{"name":"Department of Anatomopathology Edith Lucie Bongo Odimba General Hospital  Oyo Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blaise I","family":"Atipo Ibara","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Marien Ngouabi University  Brazzaville Congo"},{"name":"Gastroenterology and Internal Medicine Department Brazzaville University Hospital  Brazzaville Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,15]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"189","article-title":"Epidemiology of Helicobacter pylori infection and gastric cancer","volume":"64","author":"De Korwin JD","year":"2014","journal-title":"Rev. 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