{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T22:24:36Z","timestamp":1769120676042,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T00:00:00Z","timestamp":1707955200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Detailed clinical information regarding drug\u2010induced constipation (DIC) is limited. This study aimed to investigate the real\u2010world situation of DIC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study used data from a Japanese claims database registered from 2014 to 2021. The constipation cohort included subjects with at least one record of treated constipation, while the non\u2010constipation cohort was selected through random stratified sampling method, to match the constipation cohort by gender. The study population and control with at least one history of a known causative drug (CD) were matched 1:1 using propensity scores. The proportion of potential DIC (pDIC), the timing of diagnosis for pDIC, and the proportion of prescriptions by drug class for both the CDs and the laxatives were calculated, while logistic regression analysis was performed to explore additional associated factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 4\u2009533\u2009905 subjects, 178\u2009852 were eligible in both the study population and the control. The pDIC group comprised of 19\u2009485 patients, which accounted for 10.9% of all treated constipation subjects, while the non\u2010constipation with CD group had 10\u2009430 subjects. The median duration between the recorded CD prescription and treated constipation was 38.0\u2009days. The most frequently prescribed CD was cardiovascular drugs (47.9%). All CD classes, being male, and some comorbidities were associated with the occurrence of pDIC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The pDIC subjects accounted for about 11% of all treated constipation cases. Since DIC requires different treatment regimens compared to other constipation types, physicians should be cognizant to provide patients with optimized treatments.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.13036","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T09:40:23Z","timestamp":1707990023000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Potential drug\u2010induced constipation: A retrospective study using a Japanese claims database"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8086-1366","authenticated-orcid":false,"given":"Yusuke","family":"Karasawa","sequence":"first","affiliation":[{"name":"Medical Affairs, Viatris Pharmaceuticals Japan Inc.  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazutaka","family":"Nozawa","sequence":"additional","affiliation":[{"name":"Medical Affairs, Viatris Pharmaceuticals Japan Inc.  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Yokohama City University Graduate School of Medicine  Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-8-5"},{"key":"e_1_2_9_3_1","unstructured":"Ministry of Health Labour and Welfare.Summary Report of Comprehensive Survey of Living Conditions 2019.2020. Cited 11 Mar 2023. Available from URL:https:\/\/www.mhlw.go.jp\/english\/database\/db-hss\/dl\/report_gaikyo_2019.pdf."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07465.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20150123"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2016.01.007"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2019.11.002"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-021-01684-x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.40"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2018.12.021"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04273.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15295"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/164_2016_111"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/FAD.0b013e32833080d1"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.031"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(22)00013-5"},{"key":"e_1_2_9_17_1","volume-title":"Evidence\u2010Based Clinical Practice Guidelines for Chronic Constipation 2017 [in Japanese]","author":"Research Society for the Diagnosis and Treatment of Chronic Constipation","year":"2017"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i4.572"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(21)00111-4"},{"key":"e_1_2_9_20_1","volume-title":"Opioid Induced Constipation. 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