{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T23:38:23Z","timestamp":1793921903859,"version":"4.8.0"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>This study aimed to clarify the efficacy and safety of 48\u2010week pemafibrate treatment in patients with metabolic dysfunction\u2010associated steatotic liver disease (MASLD) complicated by dyslipidemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 110 patients diagnosed with MASLD complicated by dyslipidemia received pemafibrate at a dose of 0.1\u2009mg twice daily for 48\u2009weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The participants were 54 males and 37 females, with a median age of 63 (52\u201371) years. Besides improvement in lipid profile, significant reductions from baseline to 48\u2009weeks of treatment were found in liver\u2010related enzymes, such as aspartate aminotransferase, alanine aminotransferase (ALT), gamma\u2010glutamyl transpeptidase, and alkaline phosphatase (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001 for all). A significant decrease in the homeostasis model assessment\u2010insulin resistance (HOMA\u2010IR) was observed in patients with insulin resistance (HOMA\u2010IR\u2009\u2265\u20092.5) (4.34 at baseline to 3.89 at Week 48, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Moreover, changes in ALT were weakly correlated with those in HOMA\u2010IR (<jats:italic>r<\/jats:italic>\u2009=\u20090.34; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Regarding noninvasive liver fibrosis tests, platelets, Wisteria floribunda agglutinin\u2010positive Mac\u20102\u2010binding protein, type IV collagen 7s, and the non\u2010alcoholic fatty liver disease fibrosis score significantly decreased from baseline to Week 48. Most adverse events were Grades 1\u20132, and no drug\u2010related Grade 3 or higher adverse events were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrated that 48\u2010week pemafibrate administration improved liver\u2010related enzymes and surrogate marker of liver fibrosis in patients with MASLD. The improvement of insulin resistance by pemafibrate may contribute to the favorable effect on MASLD complicated by dyslipidemia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.13057","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T15:20:30Z","timestamp":1712071230000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Impact of pemafibrate in patients with metabolic dysfunction\u2010associated steatotic liver disease complicated by dyslipidemia: A single\u2010arm prospective study"],"prefix":"10.1002","volume":"8","author":[{"given":"Hiroki","family":"Ono","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Nippon Medical School  Tokyo 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