{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:28:29Z","timestamp":1789475309613,"version":"build-2803163510"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T00:00:00Z","timestamp":1712966400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hypertriglyceridemia\u2010induced acute pancreatitis (HTG\u2010AP) is the third most common cause of AP after gallstones and alcohol. Supportive measures, intravenous insulin, and plasmapheresis are possible treatment modalities for HTG\u2010AP; however, definitive guidelines evaluating the best therapeutic approach are not clearly established. We present a rare case of a 42\u2010year\u2010old male without known comorbidities who was found to have HTG\u2010AP. Despite early initiation of intravenous insulin and plasmapheresis and the initial decline in his triglycerides level, his condition was complicated by necrotizing pancreatitis and subsequent multi\u2010organ failure. Future studies are warranted to evaluate the role of plasmapheresis in HTG\u2010AP and its efficacy.<\/jats:p>","DOI":"10.1002\/jgh3.13061","type":"journal-article","created":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T08:33:57Z","timestamp":1712997237000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Hypertriglyceridemia\u2010induced acute necrotizing pancreatitis: Poor clinical outcomes requiring revisiting management modalities"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0181-7744","authenticated-orcid":false,"given":"Yazan","family":"Abboud","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Rutgers New Jersey Medical School  Newark New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meet","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Rutgers New Jersey Medical School  Newark New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Simmons","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Rutgers New Jersey Medical School  Newark New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kranthi","family":"Mandava","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Rutgers New Jersey Medical School  Newark New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E M","family":"Morales","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Rutgers New Jersey Medical School  Newark New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fouad","family":"Jaber","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Missouri\u2010Kansas City  Kansas City Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saqer","family":"Alsakarneh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Missouri\u2010Kansas City  Kansas City Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Ismail","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Rutgers New Jersey Medical School  Newark New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaveh","family":"Hajifathalian","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Rutgers New Jersey Medical School  Newark New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,13]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.5946\/ce.2016.152"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/4721357"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI132767"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcg.0000436438.60145.5a"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.161361"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-023-02957-3"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-0968.2002.00461.x"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annfar.2013.05.010"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0102748"},{"key":"e_1_2_4_11_1","first-page":"1","article-title":"Lipoprotein lipase, hepatic lipase and plasma lipolytic activity. Effects of heparin and a low molecular weight heparin fragment (Fragmin)","volume":"724","author":"Persson E","year":"1988","journal-title":"Acta Med. Scand. Suppl."},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(19)35496-4"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.22043"},{"key":"e_1_2_4_14_1","first-page":"1255","article-title":"Effect of plasmapheresis versus standard treatment in preventing recurrent acute pancreatitis in Chinese patients with hypertriglyceridemia","volume":"34","author":"Tang S","year":"2021","journal-title":"Pak. J. Pharm. 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