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It has become clear that multiple mechanisms acting either in isolation or together can induce gut symptoms and that appropriate interventions can lead to significant relief. What this review will explore is not the role of diet in the production of certain symptoms or symptom clusters, but rather whether a dietary intervention can beneficially alter the natural history of a gastrointestinal disease\u2014a much more demanding expectation. Yet there are examples of where a diet, if sustained, can have a long\u2010term impact on at least some of those affected by conditions such as eosinophilic esophagitis, celiac disease, food allergy, and constipation.<\/jats:p>","DOI":"10.1002\/jgh3.13063","type":"journal-article","created":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T06:23:41Z","timestamp":1716186221000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Can diet change the natural history of gastrointestinal diseases?"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4151-7180","authenticated-orcid":false,"given":"Eamonn M M","family":"Quigley","sequence":"first","affiliation":[{"name":"Lynda K and David M Underwood Center for Digestive Disorders Houston Methodist Hospital and Weill Cornell Medical College  Houston Texas 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