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However, whether 8\u2009weeks of treatment for cirrhosis may reduce treatment efficacy has not been adequately investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective, nationwide, multicenter cohort study enrolled 1275 patients with chronic hepatitis C who received GLE\/PIB therapy. The effect of liver fibrosis and treatment periods on the efficiency of GLE\/PIB therapy was investigated. The primary endpoint was the sustained virological response (SVR) rate in patients with chronic hepatitis (non\u2010cirrhosis) and cirrhosis. The association between treatment periods and liver fibrosis on the SVR after 12\u2009weeks of treatment rate was investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The SVR rates in patients with chronic hepatitis with 8\u2009weeks of treatment, chronic hepatitis with 12\u2009weeks of treatment, cirrhosis with 8\u2009weeks of treatment, and cirrhosis with 12\u2009weeks of treatment were 98.9% (800\/809), 100% (87\/87), 100% (166\/166), and 99.1% (211\/213), respectively, and were was not different among these groups (<jats:italic>P<\/jats:italic>\u2009=\u20090.4).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>GLE\/PIB therapy for chronic hepatitis C had high efficacy regardless of liver fibrosis status and treatment periods. Periods of GLE\/PIB therapy could be chosen with available modalities, and high SVR rates could be achieved regardless of the decision.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.13068","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T06:19:02Z","timestamp":1714112342000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of treatment periods on efficacy of glecaprevir and pibrentasvir in chronic hepatitis C: A nationwide, prospective, multicenter study"],"prefix":"10.1002","volume":"8","author":[{"given":"Atsuhiro","family":"Morita","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Japanese Red Cross Kyoto Daini Hospital  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuharu","family":"Tamaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Musashino Red Cross Hospital  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