{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:08:58Z","timestamp":1790662138703,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,2]],"date-time":"2024-06-02T00:00:00Z","timestamp":1717286400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Alendronate is used to treat Paget's bone disease, glucocorticoid\u2010induced osteoporosis, and postmenopausal osteoporosis because it suppresses osteoclast activity to stop bone resorption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case report<\/jats:title><jats:p>We present an exceptional case of esophagitis caused by alendronate. Blood tests and other data were normal when the patient was taken to the hospital, but an endoscopic examination revealed significant esophageal redness, erosion, and ulceration, along with pseudomembrane. The patient was given medicine after receiving a diagnosis of alendronate pill\u2010induced esophagitis based on the pathological findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This case report is a timely reminder of the importance of thorough pharmacovigilance, patient education, and smart therapeutic decision\u2010making in the context of alendronate use. To properly treat and prevent problems with the esophagus caused by alendronate, additional research is required.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.13080","type":"journal-article","created":{"date-parts":[[2024,6,2]],"date-time":"2024-06-02T09:20:13Z","timestamp":1717320013000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["From pill to pain: Alendronate\u2010induced esophageal injury\u2014A case report and review"],"prefix":"10.1002","volume":"8","author":[{"given":"Zhen","family":"Fan","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Hangzhou First People's Hospital  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9736-1384","authenticated-orcid":false,"given":"Hayat","family":"Khizar","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hangzhou First People's Hospital  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjiao","family":"Lu","sequence":"additional","affiliation":[{"name":"The Fourth School of Clinical Medicine Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anhua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Wenling First People's Hospital  Taizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Xun","sequence":"additional","affiliation":[{"name":"Department of Pathology Hangzhou First People's Hospital  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hangzhou First People's Hospital  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongfeng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Infection Control Hangzhou First People's Hospital  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0690(02)00022-8"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-023-02342-w"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199610033351403"},{"key":"e_1_2_9_5_1","first-page":"200","article-title":"Alendronate\u2010induced esophagitis in an elderly woman","volume":"2","author":"G\u00f3mez V","year":"2009","journal-title":"Int. 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