{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:57:16Z","timestamp":1753869436540,"version":"3.41.2"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T00:00:00Z","timestamp":1717372800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["Leadership 1 GTN1175744"],"award-info":[{"award-number":["Leadership 1 GTN1175744"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004752","name":"State Government of Victoria","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004752","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001202","name":"Gastroenterological Society of Australia","doi-asserted-by":"publisher","award":["AbbVie 2014"],"award-info":[{"award-number":["AbbVie 2014"]}],"id":[{"id":"10.13039\/501100001202","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001772","name":"University of New England","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001772","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>People with inflammatory bowel disease (IBD) have an increased risk of cardiovascular disease, including in younger adulthood. This may arise in part from chronic, systemic low\u2010grade inflammation. The process of atherosclerosis may begin in childhood. We sought to determine whether pediatric IBD is associated with adverse changes in arterial structure and function as a marker of early increased cardiovascular risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a case\u2013control study comparing children with IBD for a median disease duration of 2.49 (interquartile range 1.23, 4.38) years with healthy children. In a single visit, we collected baseline clinical and anthropometric data, and measured blood pressure, pulse wave velocity, carotid artery distensibility, and aortic and carotid intima\u2010media thickness. High\u2010sensitivity C\u2010reactive protein and fasting lipids were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We enrolled 81 children with IBD (40 with Crohn's disease, 40 with ulcerative colitis, and 1 with unspecified IBD) and 82 control participants. After adjusting for age, sex, body mass index <jats:italic>z<\/jats:italic>\u2010score, blood pressure, and low\u2010density lipoprotein cholesterol, there was no difference in measures of arterial structure and function in children with IBD compared with controls, nor between those with Crohn's disease or ulcerative colitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We did not show any differences in arterial structure and function in children with a history of IBD for less than 5\u2009years compared with healthy controls. IBD diagnosed in childhood may provide a window of opportunity to actively reduce standard cardiovascular risk factors and improve future cardiovascular outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.13100","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T12:56:25Z","timestamp":1717419385000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Arterial structure and function in children with inflammatory bowel disease"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3966-1183","authenticated-orcid":false,"given":"Asha","family":"Jois","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Clinical Nutrition The Royal Children's Hospital Melbourne  Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6890-3965","authenticated-orcid":false,"given":"Diana","family":"Zannino","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology and Biostatistics Unit Murdoch Children's Research Institute  Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1834-0946","authenticated-orcid":false,"given":"Anthony G","family":"Catto\u2010Smith","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Clinical Nutrition The Royal Children's Hospital Melbourne  Parkville Victoria Australia"},{"name":"Department of Paediatrics University of Melbourne  Parkville Victoria Australia"},{"name":"School of Humanities, Arts and Social Sciences, University of New England  Armidale New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meg","family":"Kaegi","sequence":"additional","affiliation":[{"name":"Inflammatory Origins Group, Infection, Immunity and Global Health Theme Murdoch Children's Research Institute  Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5692-2106","authenticated-orcid":false,"given":"Jonathan P","family":"Mynard","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University of Melbourne  Parkville Victoria Australia"},{"name":"Heart Research Group Murdoch Children's Research Institute  Parkville Victoria Australia"},{"name":"Biomedical Engineering, University of Melbourne Faculty of Engineering and Information Technology  Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Rosenbaum","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Clinical Nutrition The Royal Children's Hospital Melbourne  Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Oliver","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Clinical Nutrition The Royal Children's Hospital Melbourne  Parkville Victoria Australia"},{"name":"Department of Paediatrics University of Melbourne  Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4277-2773","authenticated-orcid":false,"given":"Winita","family":"Hardikar","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Clinical Nutrition The Royal Children's Hospital Melbourne  Parkville Victoria Australia"},{"name":"Department of Paediatrics University of Melbourne  Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5157-8983","authenticated-orcid":false,"given":"George","family":"Alex","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Clinical Nutrition The Royal Children's Hospital Melbourne  Parkville Victoria Australia"},{"name":"Department of Paediatrics University of Melbourne  Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8304-4302","authenticated-orcid":false,"given":"David","family":"Burgner","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University of Melbourne  Parkville Victoria Australia"},{"name":"Inflammatory Origins Group, Infection, Immunity and Global Health Theme Murdoch Children's Research Institute  Parkville Victoria Australia"},{"name":"Infectious Diseases Unit, Department of General Medicine The Royal Children's Hospital Melbourne  Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01323"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.11.010"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056944"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/2047487318792952"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.10.027"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc4901.100522"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1191\/1358863x04vm514ra"},{"key":"e_1_2_9_9_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0204633","article-title":"Correction: predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk \u2013 results from the PROG\u2010IMT collaboration","volume":"13","author":"Lorenz MW","year":"2018","journal-title":"PLoS One"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.192639"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3182285a81"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.03.043"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000771"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000867"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-017-2927-7"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-023-04858-9"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2017.03.022"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2007.11.011"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2010.01.002"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.12.032"}],"container-title":["JGH Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgh3.13100","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T13:31:28Z","timestamp":1719495088000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jgh3.13100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1002\/jgh3.13100"],"URL":"https:\/\/doi.org\/10.1002\/jgh3.13100","archive":["Portico"],"relation":{},"ISSN":["2397-9070","2397-9070"],"issn-type":[{"type":"print","value":"2397-9070"},{"type":"electronic","value":"2397-9070"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"2024-02-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13100"}}