{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T19:11:40Z","timestamp":1782846700654,"version":"3.54.5"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T00:00:00Z","timestamp":1721606400000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Metabolic dysfunction\u2010associated steatotic liver disease (MASLD) is associated with an increased risk of extrahepatic morbidity. We compared the incidence of cancers in adults admitted to Queensland hospitals with MASLD with that for the Queensland population and examined the association between cirrhosis and type 2 diabetes and the development of extrahepatic cancers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective study, we identified all cancers (Queensland Cancer Registry) after the first hospitalization with MASLD during Jul\u20102007 to Dec\u20102019, estimated age\u2010standardized incidence (ASI) of cancers, and compared that with the ASI in the Queensland population (incidence rate ratios [IRR]). Among the MASLD cohort, we examined the association between diabetes and cancer risk (Cox regression). Median follow\u2010up was 3.8\u2009years (54\u2009204 person\u2010years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Totally 1104 new cancers were diagnosed in 1018 patients (8.9% of 9771 non\u2010cirrhotic and 1712 adults with cirrhosis). The ASI (all cancers) of 1668.2 per 100\u2009000 person\u2010years in men (95% CI 1523.7\u20131827.4) and 1284.0 per 100\u2009000 person\u2010years in women (95% CI 1169.6\u20131408.2) was 2\u2010fold higher than that of the Queensland population (IRR\u2009=\u20091.94, 95% CI 1.75\u20132.16 and IRR\u2009=\u20091.99, 95% CI 1.78\u20132.22, respectively). Incidence of stomach cancer, unknown primary, and pancreas was 3\u2010 to 5\u2010fold higher compared to the general population (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). In multivariable analysis of the MASLD cohort, older age (e.g. \u226570\u2009years adjusted hazard ratio [adj\u2010HR]\u2009=\u20094.59, 95% CI 3.61\u20135.83), male gender (adj\u2010HR\u2009=\u20091.20, 95% CI 1.05\u20131.37), and cirrhosis (adj\u2010HR\u2009=\u20091.37, 95% CI 1.11\u20131.70) were independently associated with extrahepatic cancer risk, while diabetes was not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings will help to raise awareness among clinicians about the importance of cancer vigilance in this patient group.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.70000","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T12:06:38Z","timestamp":1721649998000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Australians with metabolic dysfunction\u2010associated steatotic liver disease have a twofold increase in the incidence of cancer"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5008-8061","authenticated-orcid":false,"given":"Elizabeth E","family":"Powell","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Princess Alexandra Hospital  Woolloongabba Queensland Australia"},{"name":"Centre for Liver Disease Research, Faculty of Medicine the University of Queensland  Brisbane Queensland Australia"},{"name":"QIMR Berghofer Medical Research Institute  Herston Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shruti","family":"Roche","sequence":"additional","affiliation":[{"name":"Royal\u00a0Brisbane and Women's Hospital  Herston Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6066-9713","authenticated-orcid":false,"given":"Babak","family":"Sarraf","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Princess Alexandra Hospital  Woolloongabba Queensland Australia"},{"name":"QIMR Berghofer Medical Research Institute  Herston Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5454-6450","authenticated-orcid":false,"given":"Gunter","family":"Hartel","sequence":"additional","affiliation":[{"name":"QIMR Berghofer Medical Research Institute  Herston Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3411-9267","authenticated-orcid":false,"given":"Richard","family":"Skoien","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Royal Brisbane and Women's Hospital  Herston Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2062-7380","authenticated-orcid":false,"given":"Barbara","family":"Leggett","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Royal Brisbane and Women's Hospital  Herston Queensland Australia"},{"name":"Faculty of Medicine, The University of Queensland  Woolloongabba Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3400-2816","authenticated-orcid":false,"given":"James","family":"O'Beirne","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Sunshine Coast University Hospital  Sunshine Coast Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8823-3006","authenticated-orcid":false,"given":"Patricia C","family":"Valery","sequence":"additional","affiliation":[{"name":"QIMR Berghofer Medical Research Institute  Herston Queensland Australia"},{"name":"Faculty of Medicine, The University of Queensland  Woolloongabba Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,22]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"gutjnl\u20102023\u2010330","article-title":"MASLD: a systemic metabolic disorder with cardiovascular and malignant complications","volume":"73","author":"Targher 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