{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T16:20:49Z","timestamp":1775060449920,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:00:00Z","timestamp":1724025600000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Severe alcoholic hepatitis (SAH) is a serious condition with few treatments. By modifying the gut\u2013liver axis, fecal microbiota transplantation (FMT) was proposed as a treatment for SAH. The purpose of this meta\u2010analysis was to evaluate the efficacy of FMT <jats:italic>versus<\/jats:italic> the standard of care (SOC) in improving SAH patient survival rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A thorough search of electronic databases was conducted till September 2023. The survival rates of SAH patients undergoing FMT <jats:italic>versus<\/jats:italic> SOC were compared. Using Review Manager 5.4, odds ratios (ORs) with 95% confidence intervals (CIs) were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The meta\u2010analysis consisted of six studies with a total of 371 patients with SAH. Patients who received FMT had significantly higher survival rates at 1 and 3\u2009months compared to those who received SOC, with pooled OR of 2.91 (95% CI: 1.56\u20135.42, <jats:italic>P<\/jats:italic>\u2009=\u20090.0008) and 3.07 (95% CI: 1.81\u20135.20, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001), respectively. However, the survival advantage disappeared after 6\u2009months (OR: 2.96, 95% CI: 0.99\u20138.85, <jats:italic>P<\/jats:italic>\u2009=\u20090.05) and 1 year of follow\u2010up (OR: 1.81, 95% CI: 0.44\u20137.46, <jats:italic>P<\/jats:italic>\u2009=\u20090.41).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This meta\u2010analysis highlights the potential of FMT to significantly improve short\u2010term survival rates in SAH patients. However, the survival benefit did not last 6\u201312\u2009months. These findings call for additional research into the effectiveness of FMT over the long term, along with strategies for extending the survival benefit.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.70007","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T09:15:22Z","timestamp":1724058922000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Impact of fecal microbiota transplantation in severe alcoholic hepatitis: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"8","author":[{"given":"Amira M","family":"Taha","sequence":"first","affiliation":[{"name":"Faculty of Medicine Fayoum University  Faiyum Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khaled","family":"Abouelmagd","sequence":"additional","affiliation":[{"name":"Cardiology Department, Faculty of Medicine Al\u2010Azhar University  New Damietta Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah A","family":"Nada","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Menoufia University  Menoufia Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelrahman M","family":"Mahmoud","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Menoufia University  Menoufia Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dang","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Corrigan Minehan Heart Center Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6909-0721","authenticated-orcid":false,"given":"Sadish","family":"Sharma","sequence":"additional","affiliation":[{"name":"Faculty of Medicine College of Medical Sciences  Bharatpur Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9750-4413","authenticated-orcid":false,"given":"Mandy","family":"Elewa","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Therapeutics, Faculty of Pharmacy Kuwait University  Kuwait City Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0805786"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(78)90401-8"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2017.469"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2016.02.004"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756283X10378925"},{"key":"e_1_2_7_7_1","first-page":"178","article-title":"Current management and future treatment of alcoholic hepatitis","volume":"16","author":"Mitchell MC","year":"2020","journal-title":"Gastroenterol. Hepatol."},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2019.08.011"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.10.003"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.913842"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-023-10525-w"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2019.12.010"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-010-9491-z"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-022-10438-0"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2016.10.029"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12664-018-0859-4"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/gastro\/goac074"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12664-023-01401-4"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-022-10312-z"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2011.244"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1412278"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11938-022-00380-3"}],"container-title":["JGH Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgh3.70007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T09:59:55Z","timestamp":1724839195000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jgh3.70007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":22,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1002\/jgh3.70007"],"URL":"https:\/\/doi.org\/10.1002\/jgh3.70007","archive":["Portico"],"relation":{},"ISSN":["2397-9070","2397-9070"],"issn-type":[{"value":"2397-9070","type":"print"},{"value":"2397-9070","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"2023-12-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70007"}}