{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T16:05:52Z","timestamp":1789833952694,"version":"4.0.1"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T00:00:00Z","timestamp":1721865600000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>We conducted a study using the Fibrosis\u20103 (FIB\u20103) index, which is the established age\u2010independent index of fibrosis in nonviral liver disease and addresses the limitations of the FIB\u20104 index in older age group, to assess the liver fibrosis risk among diverse demographic groups in the general population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed 31\u2009327 individuals who underwent health examinations between 2013 and 2020 and investigated the distribution of the FIB\u20103 index by age group. In addition, we examined the age distribution of the FIB\u20103 index stratified by background factors, such as sex, body mass index (BMI), alcohol consumption habits, and the presence or absence of fatty liver.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In terms of age\u2010specific distribution, the FIB\u20103 index remained below 1.5 in &gt;90% of cases until the age of 50\u2009years but exceeded 1.5 beyond the age of 50\u2009years, in approximately 30% among those aged 70\u2009years. Notably, the FIB\u20103 index above 31\u2009years old was significantly higher in men than in women. Among the different BMI categories, individuals with BMI\u2009&lt;\u200918.5 exhibited the highest prevalence of fibrosis. Habitual drinkers had a higher proportion with FIB\u20103. index \u22651.5, and some had FIB\u20103 index \u22652.5, raising the suspicion of advanced hepatic fibrosis. No distinct association was identified between the FIB\u20103 index and the presence of fatty liver.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The FIB\u20103 index was useful for identifying cases of advancing hepatic fibrosis in a health checkup population. Liver fibrosis progresses with age in the general population, especially among men, those with low BMI, and habitual drinkers.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.70010","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T15:21:24Z","timestamp":1721920884000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Identification of risk groups for advanced liver fibrosis in the general population using the Fibrosis\u20103 index"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3996-7502","authenticated-orcid":false,"given":"Kazuya","family":"Kariyama","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Liver Disease Center Okayama City Hospital  Okayama City Okayama 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Graduate School of Biomedical and Health Sciences, Hiroshima University  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1056-3611","authenticated-orcid":false,"given":"Tomoyuki","family":"Akita","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Infectious Disease Control and Prevention, Graduate School of Biomedical and Health Sciences, Hiroshima University  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5871-3802","authenticated-orcid":false,"given":"Takashi","family":"Kumada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Ogaki Municipal Hospital  Ogaki City Gifu Japan"},{"name":"Department of Nursing, Faculty of Nursing Gifu Kyoritsu University  Ogaki City Gifu 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