{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T06:03:45Z","timestamp":1772690625127,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:00:00Z","timestamp":1724371200000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>This is a cross\u2010sectional observational study conducted on living liver donors focusing on \u201clong\u2010term remnant liver health\u201d specifically looking at steatosis, inflammation, and fibrosis using multiparametric ultra sonological evaluation and noninvasive blood tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Multiparametric ultrasound evaluation included assessment of shear wave elastography (fibrosis), sound speed plane wave ultrasound, attenuation plane wave ultrasound (steatosis), and viscosity plane wave ultrasound (inflammation). Blood test based APRI and FIB\u20104 were calculated. Liver biopsy was performed if noninvasive evaluation pointed toward clinically relevant fibro progression (F4).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 36 donors, significant fibrosis (&gt;F2) was found in 11 donors (30.5%), seven donors (19.4%) had severe fibrosis (&gt;F3), and two donors had shear wave elastography values suggestive of cirrhosis(F4). Of these two, one donor was extensively evaluated and was found to have biopsy proven cirrhosis with endoscopic evidence of portal hypertension. The prevalence of fatty liver disease in our study group was 50%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We report the first liver donor cohort with fibroprogression and cirrhosis occurring in the remnant liver. Our donor cohort with a significant proportion having steatosis and fibroprogression underscores the importance of regular follow\u2010up of liver donors and evaluation of remnant liver.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.70015","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T11:49:39Z","timestamp":1724413779000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Steatosis, inflammation, fibroprogression, and cirrhosis in remnant liver post\u2010liver donation"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0164-9752","authenticated-orcid":false,"given":"Jeby","family":"Jacob","sequence":"first","affiliation":[{"name":"Department of Liver &amp; Digestive Care Apollo Adlux Hospital  Ernakulam Kerala India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8617-1229","authenticated-orcid":false,"given":"Amal","family":"Joseph","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Ernakulam Medical Centre  Kochi Kerala India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6075-9236","authenticated-orcid":false,"given":"Harikumar R","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Ernakulam Medical Centre  Kochi Kerala India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4039-932X","authenticated-orcid":false,"given":"Geevarghese Prajob","family":"Prasad","sequence":"additional","affiliation":[{"name":"Department of Liver &amp; Digestive Care Apollo Adlux Hospital  Ernakulam Kerala India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3829-1291","authenticated-orcid":false,"given":"Vijosh V","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Liver &amp; Digestive Care Apollo Adlux Hospital  Ernakulam Kerala India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6725-6997","authenticated-orcid":false,"given":"Lekshmi Thattamuriyil","family":"Padmakumari","sequence":"additional","affiliation":[{"name":"Department of Radiology Apollo Adlux Hospital  Ernakulam Kerala India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i18.4438"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001247"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14005"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28431"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30039-1"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-027244"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2018.07.008"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.311.6998.158"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29179"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.08.043"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11050783"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14111"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02950.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000046534.45645.47"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.23912"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2020.11.013"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.24442"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021-324243"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.14366\/usg.19031"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2021.02.029"},{"key":"e_1_2_7_22_1","article-title":"Fibroprogression and cirrhosis occurring in living liver donor: first case report","volume":"13","author":"Kumar VV","year":"2022","journal-title":"J. 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