{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T00:24:41Z","timestamp":1768004681270,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,24]],"date-time":"2024-08-24T00:00:00Z","timestamp":1724457600000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Celiac disease (CD) was shown to be associated with increased risk of developing acute pancreatitis (AP). There is a paucity of literature critically analyzing the association of CD with AP outcomes. We aimed to evaluate the impact of CD on outcomes and complications of AP in recent years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A population\u2010based analysis was performed using the National Inpatient Sample (NIS) between 2016 and 2019. Multivariable logistic regression was conducted to identify the independent impact of CD on AP outcomes while controlling for demographics and comorbidities and all patients refined diagnosis\u2010related groups (APR\u2010DRG) risk of severity subclass.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 2016 to 2019, a total of 2\u2009253\u2009730 inpatients with AP were identified, of which 4640 (0.2%) had CD. On multivariable analysis, while controlling for demographics, comorbidities, and severity of illness, CD patients had significantly decreased odds for mortality (OR\u2009=\u20090.387), pseudocyst formation (OR\u2009=\u20090.786), sepsis (OR\u2009=\u20090.707), respiratory failure (OR\u2009=\u20090.806), acute kidney injury (AKI) (OR\u2009=\u20090.804), and myocardial infarction (OR\u2009=\u20090.217), (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). However, CD patients were at significantly increased odds for deep vein thrombosis (DVT) (OR\u2009=\u20092.240) and hypotensive shock (OR\u2009=\u20091.718) (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Patients with CD had shorter lengths of stay by 0.4\u2009days and lower total charges by $12\u2009690.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our nationwide study evaluating AP outcomes in patients with CD suggests that patients with CD admitted for AP tend to have better mortality and several other outcomes compared to non\u2010CD patients. We also show that CD patients admitted for AP have a greater risk for DVT and hypotensive shock. Future studies are warranted to validate the revealed findings in CD patients admitted for AP.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.70017","type":"journal-article","created":{"date-parts":[[2024,8,24]],"date-time":"2024-08-24T17:38:55Z","timestamp":1724521135000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Celiac disease is associated with increased risk of deep vein thrombosis and hypotensive shock in patients admitted with acute pancreatitis"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0181-7744","authenticated-orcid":false,"given":"Yazan","family":"Abboud","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Rutgers New Jersey Medical School  Newark New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0123-7275","authenticated-orcid":false,"given":"Vraj P","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Rutgers New Jersey Medical School  Newark New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Jiang","sequence":"additional","affiliation":[{"name":"Karsh Division of Gastroenterology and Hepatology Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2401-7533","authenticated-orcid":false,"given":"Navya","family":"Pendyala","sequence":"additional","affiliation":[{"name":"Rutgers New Jersey Medical School  Newark New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaveh","family":"Hajifathalian","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Rutgers New Jersey Medical School  Newark New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,24]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.06.023"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000523"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.06.002"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000001657"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.025411"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-07-031104"},{"key":"e_1_2_5_8_1","unstructured":"Healthcare Cost and Utilization Project AfHRaQ R MD.Introduction to the HCUP National (Nationwide) Inpatient Sample (NIS) 2019.2021. 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