{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T04:34:57Z","timestamp":1783571697660,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T00:00:00Z","timestamp":1724630400000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014421","name":"EA Pharma Co., Ltd.","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014421","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004820","name":"Mochida Pharmaceutical Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004820","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Elobixibat is a triple mode of action laxative that increases water secretion into the colon, promotes colonic motility, and reestablishes the defecation desire. This study aims to evaluate the effectivity and safety of elobixibat in chronic constipation (CC) patients refractory to conventional laxatives.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A single\u2010center retrospective observational study was conducted in refractory CC patients diagnosed according to the Rome IV criteria and received elobixibat between April 2018 and June 2022 at Osaka Saiseikai Nakatsu Hospital. Data were collected for spontaneous bowel movement (SBM), Bristol stool form scale (BSFS) scores, abdominal symptoms, and adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eligible 311 patients were selected for the analysis. Two\u2010week Elobixibat treatment significantly increased SBM (times\/week) from 2.9\u2009\u00b1\u20091.9 to 4.3\u2009\u00b1\u20091.9 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). The BSFS score improved significantly from 3.2\u2009\u00b1\u20091.7 to 4.4\u2009\u00b1\u20091.4 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). The percentages of patients with hard stool were decrease and that with normal stools were increase. Improvements in abdominal symptoms (sensation of incomplete bowel evacuation, straining, abdominal pain and distention, and difficulty defecating) were also significant (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). These constipation symptoms were improved irrespective of patient characteristics or previous laxatives. The 43.9% of previous laxatives were discontinued at the start of or after starting elobixibat treatment. A few adverse events were observed, elobixibat was well tolerated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Elobixibat was effective in patients who were refractory to other laxatives, irrespective of previous therapy or patient characteristics. Elobixibat may contribute to resolving polypharmacy with single mode of action laxatives.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.70019","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T05:30:00Z","timestamp":1724736600000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy and safety of elobixibat in combination with or switched from conventional treatments of chronic constipation: A retrospective observational study"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9026-4808","authenticated-orcid":false,"given":"Takaaki","family":"Eguchi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Osaka Saiseikai Nakatsu Hospital  Osaka Japan"},{"name":"Department of General Medicine Shiga University of Medical Science Hospital  Shiga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Inatomi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine Shiga University of Medical Science  Shiga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhei","family":"Shintani","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine Shiga University of Medical Science  Shiga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Momose","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Osaka Saiseikai Nakatsu Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoya","family":"Sako","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Osaka Saiseikai Nakatsu Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megumi","family":"Takagi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Osaka Saiseikai Nakatsu Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiki","family":"Fumihara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Osaka Saiseikai Nakatsu Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Osaka Saiseikai Nakatsu Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Katayama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Osaka Saiseikai Nakatsu Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Morisawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Osaka Saiseikai Nakatsu Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5052-3754","authenticated-orcid":false,"given":"Takumi","family":"Ota","sequence":"additional","affiliation":[{"name":"Medical Affairs Department Mochida Pharmaceutical Co., Ltd.  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