{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:57:21Z","timestamp":1753869441116,"version":"3.41.2"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T00:00:00Z","timestamp":1725235200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>We aimed to investigate whether individuals with low pepsinogen I levels differed from those with normal pepsinogen I levels in terms of proton pump inhibitors (PPIs) use, referral to gastroscopy, and findings on gastroscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum pepsinogen I was measured in 518 persons (mean age 51.6, SD 8.8; 49% women). A medical chart review focused on PPI prescriptions and gastroscopic findings in the follow\u2010up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with serological atrophic gastritis (pepsinogen I\u2009&lt;\u200928\u2009\u03bcg\/L) had higher body mass index (27.5 <jats:italic>vs<\/jats:italic> 26.2\u2009kg\/m<jats:sup>2<\/jats:sup>; <jats:italic>P<\/jats:italic>\u2009=\u20090.007), were less likely to be current smokers (8% <jats:italic>vs<\/jats:italic> 17%; <jats:italic>P<\/jats:italic>\u2009=\u20090.025), and had higher prevalence of <jats:italic>Helicobacter pylori<\/jats:italic> seropositivity (57% <jats:italic>vs<\/jats:italic> 36%; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) compared with those without. During follow\u2010up (mean 21.4\u2009years, SD 6.5\u2009years), the patients with serological atrophic gastritis had more often findings of atrophic gastritis or gastric polyps on gastroscopy (20% <jats:italic>vs<\/jats:italic> 8%; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), despite no differences in the mean number of gastroscopies per 1000 person\u2010years (33 <jats:italic>vs<\/jats:italic> 23; <jats:italic>P<\/jats:italic>\u2009=\u20090.19) and the mean prescribed PPI dose (omeprazole equivalents) per year (1064\u2009mg <jats:italic>vs<\/jats:italic> 1046\u2009mg; <jats:italic>P<\/jats:italic>\u2009=\u20090.95). Persons with serological atrophic gastritis had lower odds of being prescribed PPIs at least once (odds ratio [95% confidence interval]: 0.58 [0.35\u20130.96]), but there was no significant difference in the chance of being referred to gastroscopy at least once (1.15 [0.70\u20131.96]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Persons with serological atrophic gastritis were less likely to be prescribed PPIs. Persons with serological atrophic gastritis had more often gastric polyps and atrophic gastritis when referred to gastroscopy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.70022","type":"journal-article","created":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T11:46:15Z","timestamp":1725277575000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Significance of serological atrophic gastritis on proton pump inhibitor prescriptions and referrals to gastroscopy in the general population"],"prefix":"10.1002","volume":"8","author":[{"given":"Tor","family":"Persson","sequence":"first","affiliation":[{"name":"Department of Public Health and Clinical Medicine Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"S\u00f6derberg","sequence":"additional","affiliation":[{"name":"Department of Public Health and Clinical Medicine Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9412-2871","authenticated-orcid":false,"given":"Minkyo","family":"Song","sequence":"additional","affiliation":[{"name":"Laboratory of Epidemiology and Population Sciences National Institute on Aging, National Institute of Health  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5607-0118","authenticated-orcid":false,"given":"Pontus","family":"Karling","sequence":"additional","affiliation":[{"name":"Department of Public Health and Clinical Medicine Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(82)90176-7"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-22-0372"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-21-1328"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0142080"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.02.018"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2010.12.012"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ueg2.12267"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v28.i8.853"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2015.04.001"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2005.00348.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-008-0576-5"},{"key":"e_1_2_6_13_1","first-page":"304","article-title":"Evaluation of western blot CagA seropositivity in Helicobacter pylori\u2010seropositive and \u2010seronegative subjects","volume":"12","author":"Siman JH","year":"2005","journal-title":"Clin. 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