{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T05:12:24Z","timestamp":1768281144658,"version":"3.49.0"},"reference-count":41,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T00:00:00Z","timestamp":1728259200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>This study aimed to clarify whether several single\u2010nucleotide polymorphisms (SNPs)\u2010related chronic pancreatitis such as carboxypeptidase A1 (<jats:italic>CPA1<\/jats:italic>), carboxypeptidase B1 (<jats:italic>CPB1<\/jats:italic>), Gamma\u2010glutamyltransferase 1 (<jats:italic>GGT1<\/jats:italic>), G\u2010protein\u2010coupled receptor Class C Group 6 Member A (<jats:italic>GPRC6A<\/jats:italic>), and serine protease inhibitor, Kazal type 1 (<jats:italic>SPINK\u20101<\/jats:italic>) genotypes were associated with clinical characteristics of patients with intraductal papillary mucinous neoplasm (IPMN) and worrisome features of IPMN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 100 patients with IPMN and 116 patients as a control. Serum p\u2010amylase, lipase, trypsin, phospholipase A2 (PLA2), and elastase\u20101 levels were measured. An Olympus EUS (GF\u2010UCT 260) was used to perform endosonography in 100 patients with IPMN. Total EUS score was evaluated using endosonography. DNA was isolated from the duodenal tissue using a commercial system and polymerase chain reaction (PCR) was performed on 7500 Fast PCR System.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no associations between glucose tolerances, lipid levels and genotypes of <jats:italic>CPA1<\/jats:italic>, <jats:italic>GGT1<\/jats:italic>, <jats:italic>GPRC6A<\/jats:italic>, and <jats:italic>SPINK\u20101<\/jats:italic> in patients with IPMN. <jats:italic>CPA1<\/jats:italic> genotype was significantly associated with the pathophysiology of IPMN. Then, <jats:italic>GGT1<\/jats:italic> genotype was also significantly associated with EUS total score and the size of cyst more than 20\u2009mm and more than 30\u2009mm as one of worrisome features of IPMN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Genotypes of carboxypeptidase A1 and gamma\u2010glutamyltransferase 1 may be useful tools for the diagnosis and the predictor of worrisome features of IPMN.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.70031","type":"journal-article","created":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T06:33:54Z","timestamp":1728369234000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Genotypes of carboxypeptidase A1 and gamma\u2010glutamyltransferase 1 may be useful tools for the diagnosis and the predictor of worrisome features of intraductal papillary mucinous neoplasm in 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