{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T03:15:35Z","timestamp":1784344535721,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Spectrum of esophageal motility disorders may differ according to age, but studies on this are scanty, contradictory, and included small number of patients. Accordingly, we retrospectively analyzed data of a large sample of patients to study the spectrum of esophageal motility disorders in relation to age, and to evaluate the clinical profile and high\u2010resolution manometry parameters and achalasia subtypes according to Chicago IV criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Of 909 patients evaluated by high\u2010resolution water perfusion or solid\u2010state manometry during a 3\u2010year period, data on 801 were finally analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Achalasia cardia was the commonest motility disorder of esophagus in this large study and type II was the commonest subtype. There was no difference in clinical and manometry parameters among elderly patients as compared to younger patients with achalasia. Type I achalasia patients less often had chest pain and tended to have nocturnal coughing spells more often, and patients with achalasia experiencing chest pain tended to have higher distal contractile integral (DCI) than those not having pain irrespective of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The clinical and high\u2010resolution manometry parameters among young and elderly patients with esophageal motility disorders are quite comparable. However, these differed in relation to achalasia subtypes and symptoms. Type I achalasia patients less often had chest pain and those experiencing chest pain tended to have higher DCI values than those not having pain irrespective of age.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.70040","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T10:07:57Z","timestamp":1733998077000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical and high\u2010resolution manometry of 801 patients with esophageal dysmotility, including achalasia, in relation to age"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0221-8495","authenticated-orcid":false,"given":"Uday C","family":"Ghoshal","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Sanjay Gandhi Postgraduate Institute of Medical Sciences  Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akshay","family":"Kulkarni","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sanjay Gandhi Postgraduate Institute of Medical Sciences  Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek V","family":"Shirol","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sanjay Gandhi Postgraduate Institute of Medical Sciences  Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anshuman","family":"Elhence","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sanjay Gandhi Postgraduate Institute of Medical Sciences  Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bushra","family":"Fatima","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sanjay Gandhi Postgraduate Institute of Medical Sciences  Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand P","family":"Agrahari","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sanjay Gandhi Postgraduate Institute of Medical Sciences  Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asha","family":"Misra","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sanjay Gandhi Postgraduate Institute of Medical Sciences  Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1741064"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14058"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.12.289"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1740490"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i24.3050"},{"key":"e_1_2_6_7_1","first-page":"2","article-title":"Systematic review of pharyngeal and esophageal manometry in healthy or dysphagic older persons (>60\u2009years)","volume":"3","author":"Cock C","year":"2018","journal-title":"Geriatrics (Basel)"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(16)46230-4"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000650"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2017.11.012"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2050.2009.00962.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12664-010-0002-7"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-005-2903-3"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.08.038"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.08.035"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2010.06298.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2006.04720.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01300761"},{"key":"e_1_2_6_19_1","first-page":"231","article-title":"Clinical and manometric findings on elderly patients with achalasia","volume":"76","author":"Ortiz\u2010Olvera N","year":"2011","journal-title":"Rev. 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