{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T17:05:26Z","timestamp":1784307926239,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,12,8]],"date-time":"2024-12-08T00:00:00Z","timestamp":1733616000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>The treatment for <jats:italic>Helicobacter pylori<\/jats:italic> is considered to be a combination of several strict regimens, with patients' dissatisfaction and poor compliance. Probiotics are effective in patients' antibiotic regimens. This study investigated the efficacy of the Pyloshot probiotic in combination with standard four\u2010drug therapy in patients with <jats:italic>H. pylori<\/jats:italic> infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is an interventional study. The study population consisted of patients with <jats:italic>H. pylori<\/jats:italic> infection who were selected using the convenience sampling method and were randomly divided into two groups: (i) A or standard four\u2010drug therapy (amoxicillin\u2010clarithromycin\u2010bismuth\u2010pantoprazole) plus two placebo capsules (80 cases). (ii) B or Pyloshot group (standard four\u2010drug therapy plus 2 Pyloshot probiotic capsules) (90 cases). Patients were followed up for 1\u2009month after treatment completion. Eradication of <jats:italic>H. pylori<\/jats:italic> was also assessed using the stool antigen test. Data were analyzed using SPSS (v.26) statistical software.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Based on the results from the present study, the number of negative stool antigen tests in group A was less than that in group B, and no statistically significant relationship was found between <jats:italic>H. pylori<\/jats:italic> eradication (based on stool antigen test) and the studied groups (<jats:italic>P<\/jats:italic>\u2009=\u20090.20). There was a statistically significant relationship between vomiting (<jats:italic>P<\/jats:italic>\u2009=\u20090.03), diarrhea (<jats:italic>P<\/jats:italic>\u2009=\u20090.04), constipation (<jats:italic>P<\/jats:italic>\u2009=\u20090.01), and headache (<jats:italic>P<\/jats:italic>\u2009=\u20090.04); vomiting and constipation were most frequent in the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Based on the results of the present study, there was no significant difference between the effectiveness of treatment with Pyloshot probiotic and the standard four\u2010drug therapy in patients with <jats:italic>H. pylori<\/jats:italic> infection. However, the incidence of side effects was lower in the group treated with Pyloshot.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.70046","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T07:15:12Z","timestamp":1733728512000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy of Pyloshot in combination with standard four\u2010drug antimicrobial treatment for <i>Helicobacter pylori<\/i> eradication: A randomized clinical trial"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3542-7944","authenticated-orcid":false,"given":"Hossein","family":"Azad","sequence":"first","affiliation":[{"name":"Clinical Research of Development Unit, Shahid Beheshti Hospital Qom University of Medical Sciences  Qom Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3942-0681","authenticated-orcid":false,"given":"Ahmad","family":"Hormati","sequence":"additional","affiliation":[{"name":"Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Shariati Hospital, Department of Internal Medicine, School of Medicine Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5702-7410","authenticated-orcid":false,"given":"Seyed S","family":"Sarkeshikian","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Diseases Research Center Qom University of Medical Sciences  Qom Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abolfazl","family":"Mohammadbeigi","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology, School of Health Research Center for Environmental Pollutants Qom University of Medical Sciences  Qom Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemehsadat","family":"Razavinia","sequence":"additional","affiliation":[{"name":"General physician, Qom University of Medical Sciences  Qom Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Eshaghi Far","sequence":"additional","affiliation":[{"name":"Master of Zoology Physiology  Qom Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6828-7800","authenticated-orcid":false,"given":"Mehdi","family":"Pezeshgi Modarres","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Diseases Research Center Qom University of Medical Sciences  Qom Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpgasthep0634"},{"key":"e_1_2_9_3_1","first-page":"54","article-title":"Helicobacter pylori infection and gastric MALT lymphoma","volume":"2005","author":"Lehours P","year":"1995","journal-title":"Rocz. 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