{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:33:40Z","timestamp":1792514020310,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,11,24]],"date-time":"2024-11-24T00:00:00Z","timestamp":1732406400000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hepatitis B virus (HBV) infection causes liver disease, including hepatocellular carcinoma. Controlling viral activity is crucial to reducing complications. Tenofovir may offer benefits over entecavir, but it is unclear if switching from entecavir to tenofovir improves outcomes. This study assesses the clinical impact of switching to tenofovir therapy for chronic HBV infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Following the PRISMA guidelines, we conducted a literature search within the Cochrane Library, PubMed, MEDLINE, Embase, and Scopus for studies of patients with HBV infection who were switched to tenofovir from entecavir or were maintained on entecavir. Both formulations of tenofovir, that is, tenofovir disoproxil fumarate and tenofovir alafenamide were included and analyzed in subgroup analysis. Meta\u2010analyses were performed with RevMan 5.4 using a random\u2010effects model, with statistical significance set at <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of eight studies, comprising 833 patients, were included in the meta\u2010analysis. Tenofovir showed a significantly higher likelihood of achieving complete virological response (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 5.60; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 3.51\u20138.94; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.00001) and a greater reduction in <jats:styled-content style=\"fixed-case\">HBV DNA<\/jats:styled-content> levels (<jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content> \u22121.03 log <jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> \u22121.69 to \u22120.36; <jats:italic>p<\/jats:italic>\u2009=\u20090.002) compared to entecavir. However, there was no significant difference in <jats:styled-content style=\"fixed-case\">HBsAg<\/jats:styled-content> reduction or <jats:styled-content style=\"fixed-case\">HBeAg<\/jats:styled-content> seroconversion between the two groups. <jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content> reductions were not statistically significant overall, although entecavir showed better outcomes in subgroup analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Switching from entecavir to tenofovir improves virological response and reduces HBV DNA levels, but shows no significant advantage in HBsAg reduction, HBeAg seroconversion, or overall, ALT reduction.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.70055","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T06:05:26Z","timestamp":1732514726000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Switching to Tenofovir Therapy Versus Continuation of Entecavir for Patients With Hepatitis B Virus Infection: A\u00a0Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4010-7545","authenticated-orcid":false,"given":"Muhammad","family":"Shahzil","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Milton S. Hershey Medical Center, The Pennsylvania State University  Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ammad Javaid","family":"Chaudhary","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Henry Ford Hospital  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talha","family":"Kashif","sequence":"additional","affiliation":[{"name":"Department of Medicine King Edward Medical University  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Akram","family":"Qureshi","sequence":"additional","affiliation":[{"name":"Department of Medicine King Edward Medical University  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anza","family":"Muhammad","sequence":"additional","affiliation":[{"name":"Department of Medicine King Edward Medical University  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faiza","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Medicine King Edward Medical University  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Saad","family":"Faisal","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Henry Ford Hospital  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2863-8352","authenticated-orcid":false,"given":"Muhammad Ali","family":"Khaqan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine John H. Stroger, Jr. Hospital of Cook County  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassam","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology ECU Health  Greenville North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yara","family":"Dababneh","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Henry Ford Hospital  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilip","family":"Moonka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Henry Ford Hospital  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.5761"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2009.01117.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.04.061"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-008-9080-3"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-023-00990-w"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0098865"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067710"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22211"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3282ffde91"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23190"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2727.98664"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-023-03024-7"},{"issue":"372","key":"e_1_2_7_14_1","article-title":"Statement: An Updated Guideline for Reporting Systematic Reviews","volume":"29","author":"Page M. 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