{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:57:19Z","timestamp":1753869439603,"version":"3.41.2"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T00:00:00Z","timestamp":1732492800000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Nationwide US data on readmission rates for patients with cirrhosis admitted with hepatorenal syndrome (HRS) is lacking. We reviewed 30\u2010day readmission rates after HRS\u2010related hospitalizations, the associated predictors of readmissions, and their impact on resource utilization and mortality in the United States.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We identified all adults admitted with HRS between 2016 and 2019 using the Nationwide Readmission database of the Agency for Healthcare Research and Quality's Healthcare Cost and Utilization Project. The primary outcome was all\u2010cause 30\u2010day readmission rate. Secondary outcomes were inpatient mortality rate, predictors of readmission, and resource utilization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 245\u2009850 hospitalizations of patients admitted for HRS in the United States from 2016 to 2019. Of these, 214\u2009890 met the inclusion criteria. Mean age was 59.16\u2009years, and 61.31% were males. Medicare was the most common primary payer (44.82%) followed by Medicaid (25.58%). The readmission rate was 24.6% within 30\u2009days of discharge from index hospitalization. The most common cause of readmission was alcoholic cirrhosis with ascites (14.87%), followed by sepsis (9.32%) and unspecified hepatic failure (9%). The in\u2010hospital mortality rate for index hospitalization was 29.52% and 14.35% among those readmitted within 30\u2009days. The mean length of stay (12.33\u2009days vs. 7.15\u2009days, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and hospitalization costs ($44\u2009903 vs. $22\u2009353, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) were higher for index hospitalizations than readmissions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study demonstrated that all\u2010cause 30\u2010day readmission and in\u2010hospital mortality rates after the development of HRS were strikingly high. This warrants health policies and interventions at the institutional level, including close post\u2010hospital discharge follow\u2010up, to decrease readmission rates, improve patient outcomes, and reduce cost burden.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.70062","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T04:57:56Z","timestamp":1732597076000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Readmission Rate, Predictors, Outcomes, and Burden of Readmission of Hepatorenal Syndrome in the United States: A Nationwide Analysis"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1240-6441","authenticated-orcid":false,"given":"Abdullah","family":"Sohail","sequence":"first","affiliation":[{"name":"Department of Internal Medicine University of Iowa Hospitals and Clinics  Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ammad J.","family":"Chaudhary","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Henry Ford Hospital  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Mujtaba","family":"Bhinder","sequence":"additional","affiliation":[{"name":"Charleston Area Medical Center  West Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khadija","family":"Zahid","sequence":"additional","affiliation":[{"name":"Gujranwala Medical College  Gujranwala Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyle","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Gastroenterology and Hepatology University of Iowa Hospitals and Clinics  Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/13696998.2019.1580201"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.236133"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1665-2681(19)31491-7"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14-1925"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/108139"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/lv.2000.7569"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01340406"},{"issue":"7","key":"e_1_2_7_9_1","article-title":"A Review of Hepatorenal Syndrome","volume":"13","author":"Subedi A.","year":"2021","journal-title":"Cureus"},{"issue":"1","key":"e_1_2_7_10_1","first-page":"11","article-title":"Hepatorenal Syndrome","volume":"28","author":"Ng C. 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Agency for Healthcare Research and Quality \u201dAgency for Healthcare Research and Quality https:\/\/www.hcup\u2010us.ahrq.gov\/db\/nation\/nrd\/Introduction_NRD_2019.pdf."},{"volume-title":"International Statistical Classification Of of Diseases And and Related Health Problems, 10th revision (ICD\u201010)","author":"World Health Organization","key":"e_1_2_7_17_1"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.17232"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgast-2020-000485"},{"key":"e_1_2_7_20_1","unstructured":"\u201cHCUP Cost\u2010to\u2010Charge Ratio (CCR) Files: Agency for Healthcare Research and Quality \u201dHealthcare Cost and Utilization Project (HCUP) https:\/\/hcup\u2010us.ahrq.gov\/db\/ccr\/costtocharge.jsp."},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000521288"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58121859"},{"issue":"8","key":"e_1_2_7_23_1","article-title":"Frequency of Hepatorenal Syndrome Among Patients With Cirrhosis and Outcome After Treatment","volume":"12","author":"Fida S.","year":"2020","journal-title":"Cureus"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastrohep.2021.02.007"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ygh2.429"}],"container-title":["JGH Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgh3.70062","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T08:00:53Z","timestamp":1732780853000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jgh3.70062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":24,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1002\/jgh3.70062"],"URL":"https:\/\/doi.org\/10.1002\/jgh3.70062","archive":["Portico"],"relation":{},"ISSN":["2397-9070","2397-9070"],"issn-type":[{"type":"print","value":"2397-9070"},{"type":"electronic","value":"2397-9070"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"2024-06-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70062"}}