{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:31:10Z","timestamp":1785771070097,"version":"3.56.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T00:00:00Z","timestamp":1736899200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Lubiprostone increases chloride and water secretion in the intestines, and several studies have demonstrated the efficacy of lubiprostone in treating functional constipation. Several new clinical trials have emerged since the previous meta\u2010analysis conducted in 2020. We conducted this updated meta\u2010analysis to assess clinical efficacy of lubiprostone in these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic search was conducted on MEDLINE, Cochrane, and Scopus. Randomized controlled trials published between July 2019 and June 2024 were selected. Cochrane's RoB 2 tool was used to assess the risk of bias. A meta\u2010analysis was performed and findings were presented using forest plots.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 14 studies, comprising 4550 patients, were included in the review. Only 12 studies were pooled in the meta\u2010analysis. Lubiprostone was associated with greater spontaneous bowel movements (SBM) per week (RR 1.454, 95% CI 1.193\u20131.771) and SBM within 24\u2009h (RR 1.790, 95% CI 1.491\u20132.150) in patients with chronic idiopathic constipation (CIC). However, it was not associated with abdominal pain in either arm (RR 1.415, 95% CI 0.873\u20132.294). In opioid\u2010induced constipation (OIC), lubiprostone increased SBM within 24\u2009h (RR 1.277, 95% CI 1.105\u20131.475) but did not significantly affect abdominal pain (RR 4.321, 95% CI 0.624\u201329.941). Lubiprostone improved all selected SBM\u2010related and abdominal pain outcomes in patients with irritable bowel syndrome with constipation (IBS\u2010C).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Lubiprostone significantly improves all SBM\u2010related outcomes. Owing to its good safety and efficacy profile, lubiprostone can be used in the combination regimens for management of CIC, IBS\u2010C, and OIC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.70070","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T06:44:21Z","timestamp":1737009861000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Efficacy of Lubiprostone in Patients of Constipation: An\u00a0Updated Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"9","author":[{"given":"Umar","family":"Akram","sequence":"first","affiliation":[{"name":"Department of Medicine Allama Iqbal Medical College  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8302-2173","authenticated-orcid":false,"given":"Obaid Ur","family":"Rehman","sequence":"additional","affiliation":[{"name":"Department of Medicine Services 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