{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:26:51Z","timestamp":1788280011172,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100031028","name":"Rajavithi Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031028","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A proportion of patients with functional dyspepsia (FD) have inadequate symptom control with proton pump inhibitors (PPIs) treatment. Vonoprazan demonstrates higher efficacy in acid reduction than PPI; however, the existing efficacy data for vonoprazan in treating PPI\u2010refractory FD is limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This double\u2010blinded, randomized controlled trial study was conducted at Rajavithi Hospital, Bangkok between December 2022 and 2023. Patients with FD who were unresponsive to the standard dose PPI were randomly assigned (1:1) to receive either 10\u2009mg or 20\u2009mg of vonoprazan for a 4\u2010week duration, with a subsequent 4\u2010week follow\u2010up after treatment. The primary outcome was changes in the Global Overall Symptoms Scale (GOSS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty patients were randomized without significant differences in baseline characteristics between both groups. The mean GOSS between the 10\u2010mg vonoprazan and the 20\u2010mg vonoprazan arm were 25.73 and 26.17 at week 0, 14.33 and 15.50 at week 2, 9.37 and 10.04 at week 4, and 9.79 and 9.33 at week 8, respectively (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 vs. baseline and <jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05 between groups). The quality of life was improved, with the Nepean dyspepsia index changing \u22124.13 and \u22124.25 at week 4, respectively (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 vs. baseline; <jats:italic>p<\/jats:italic>\u2009=\u20090.853 between groups). Symptom response rates (&gt;\u200950% improvement in GOSS) were 72.4% and 75.9% at week 8, respectively (<jats:italic>p<\/jats:italic>\u2009=\u20090.24 between groups). No serious adverse events were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Vonoprazan demonstrated significant effects in the alleviation of symptoms in PPI\u2010refractory FD patients. There was no statistically significant difference in symptom alleviation between the 10\u2009mg and 20\u2009mg doses of vonoprazan.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.70082","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T08:20:46Z","timestamp":1734682846000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy of Vonoprazan 10\u2009mg and 20\u2009mg for Patients With Proton Pump Inhibitor\u2010Refractory Functional Dyspepsia: A Double\u2010Blinded, Randomized Study"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8842-032X","authenticated-orcid":false,"given":"Chalermrat","family":"Bunchorntavakul","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Rajavithi Hospital, College of Medicine Rangsit University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pantaree","family":"Jaigla","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Rajavithi Hospital, College of Medicine Rangsit University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.011"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i17.2661"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.17414"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2017.154"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ueg2.12090"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm18081"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16295"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.111.185314"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15641"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.09.041"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph17060698"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2024.06.038"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3892\/br.2016.828"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.15403\/jgld-4837"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.02774.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1999.00445.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.12.247"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314010"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.01.018"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13121"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.09.033"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13461"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-023-08162-2"}],"container-title":["JGH Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgh3.70082","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T04:38:25Z","timestamp":1735533505000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jgh3.70082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":24,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1002\/jgh3.70082"],"URL":"https:\/\/doi.org\/10.1002\/jgh3.70082","archive":["Portico"],"relation":{},"ISSN":["2397-9070","2397-9070"],"issn-type":[{"value":"2397-9070","type":"print"},{"value":"2397-9070","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"2024-10-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70082"}}