{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T14:13:42Z","timestamp":1779027222998,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,19]],"date-time":"2025-01-19T00:00:00Z","timestamp":1737244800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Oxidative stress has been considered a factor in the development of post\u2010endoscopic retrograde cholangiopancreatography pancreatitis (PEP). The present clinical trial evaluated whether adding intravenous mesna to rectal indomethacin could prevent or alleviate PEP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An open\u2010labeled clinical trial was done on 698 participants undergoing endoscopic retrograde cholangiopancreatography (ERCP). Eligible patients received 100\u2009mg indomethacin suppository 30\u2009min before undergoing ERCP. Randomly, the participants received 400\u2009mg intravenous mesna or nothing 30\u2009min before doing the procedure. The PEP incidence and degree were measured in the patients as the main outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The total rate of PEP was equal to 13.7%. No significant difference was seen in the rate and severity of PEP between the mesna plus indomethacin and indomethacin alone arms (14% vs. 13.4%, respectively, <jats:italic>p<\/jats:italic>\u2009=\u20090.671). In high\u2010risk patients, PEP rate and severity were lower in the mesna plus indomethacin group compared with indomethacin alone group and the statistical analysis showed that the difference was significant (41.7% vs. 51.8%, respectively, <jats:italic>p<\/jats:italic>\u2009=\u20090.033).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In high\u2010risk patients undergoing ERCP, a combination of intravenous mesna plus rectal indomethacin may decrease the PEP rate and severity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.70083","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T06:53:27Z","timestamp":1737356007000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of 2\u2010Mercaptoethane Sulfonate Sodium (MESNA) in the Prevention of Pancreatitis After Endoscopic Retrograde Cholangiopancreatography: A Randomized Open Label Trial"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9580-2676","authenticated-orcid":false,"given":"Amir","family":"Sadeghi","sequence":"first","affiliation":[{"name":"Gastroenterology and Liver Diseases Research Center Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0439-955X","authenticated-orcid":false,"given":"Hesamoddin","family":"Samar","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy School of Pharmacy, Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6414-5557","authenticated-orcid":false,"given":"Mohammad","family":"Abbasinazari","sequence":"additional","affiliation":[{"name":"Anesthesiology Research Center Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2471-4485","authenticated-orcid":false,"given":"Parvaneh","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"Gastroenterology and Liver Diseases Research Center Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3858-625X","authenticated-orcid":false,"given":"Ali","family":"Abazarikia","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy School of Pharmacy, Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4358-470X","authenticated-orcid":false,"given":"Shadi","family":"Ziaie","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy School of Pharmacy, Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.5152\/tjg.2023.23175"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1505202"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1075-4080"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58091261"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000787"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2017.06.009"},{"key":"e_1_2_7_8_1","first-page":"579","article-title":"Does Allopurinol Prevent Post Endoscopic Retrograde Cholangio\u2010Pancreatography Pancreatitis? A Randomized Double Blind Trial","volume":"49","author":"Abbasinazari M.","year":"2011","journal-title":"Acta Medica Iranica"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-200408000-00018"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.5946\/ce.2022.165"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.5812\/jcma-145362"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1993.11.1.173"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-020-06072-1"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1023741518385"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.23902\/trkjnat.1123792"},{"key":"e_1_2_7_16_1","first-page":"137","article-title":"The Revised Atlanta Classification Is the Strongest Predictor of Mortality in Patients With Acute Pancreatitis: A Study on 358 Patients","volume":"40","author":"Anikhindi S. A.","year":"2020","journal-title":"Tropical Gastroenterology"},{"key":"e_1_2_7_17_1","first-page":"248","article-title":"Post ERCP Changes in Oxidative Stress as a Possible Cause of Pancreatitis","volume":"18","author":"Shiller M.","year":"2017","journal-title":"Journal of the Pancreas: JOP"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/16.3.542"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i30.9189"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000001531"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.34172\/aim.2022.25"}],"container-title":["JGH Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgh3.70083","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T09:29:30Z","timestamp":1738056570000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jgh3.70083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/jgh3.70083"],"URL":"https:\/\/doi.org\/10.1002\/jgh3.70083","archive":["Portico"],"relation":{},"ISSN":["2397-9070","2397-9070"],"issn-type":[{"value":"2397-9070","type":"print"},{"value":"2397-9070","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-10-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70083"}}