{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:57:23Z","timestamp":1753869443353,"version":"3.41.2"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>It is important for endoscopist to diagnose the lesion redness. In this study, we focused on the redness of duodenal bulb. We objectively analyzed the changes in redness of the duodenal bulb using linked color imaging (LCI) with chromatic indicators.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seven endoscopists observed the duodenal bulb with white light imaging (WLI) and LCI, and evaluated them by visual analogue scale (VAS) for the degree of redness. The difference in VAS between WLI and LCI was defined as \u0394VAS. All images were quantified by the Comission Internationale de l'Eclariage\u2010<jats:italic>L<\/jats:italic>*<jats:italic>a<\/jats:italic>*<jats:italic>b<\/jats:italic>* color space. Values related to color differences (\u0394<jats:italic>E<\/jats:italic>*, \u0394<jats:italic>L<\/jats:italic>*, \u0394<jats:italic>a<\/jats:italic>*, and \u0394<jats:italic>b<\/jats:italic>*) were calculated from the two images of WLI and LCI. Multiple regression analysis was performed for the factors with the health checkup correlated with \u0394VAS and the correlation between \u0394VAS and \u0394<jats:italic>E<\/jats:italic>*, \u0394<jats:italic>L<\/jats:italic>*, \u0394<jats:italic>a<\/jats:italic>*, and \u0394<jats:italic>b<\/jats:italic>* was also examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The analysis prospectively included 1144 examinees. In multiple regression analysis, it revealed that sex (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.5847, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) and metabolic syndrome (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.4138, <jats:italic>p<\/jats:italic>\u2009=\u20090.0012) were the factors independently influenced \u0394VAS. And only \u0394<jats:italic>a<\/jats:italic>*, a chromatic index for changes in the degree of redness, showed a statistically and considerably positive correlation with \u0394VAS (<jats:italic>r<\/jats:italic>\u2009=\u20090.4529, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>To evaluate the difference in the degree of redness between WLI and LCI of duodenal bulb in esophagogastroduodenoscopy may help in early detection of metabolic syndrome, which rarely has symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.70096","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T08:34:02Z","timestamp":1736757242000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Significance of Endoscopic Redness of Duodenum in Health Checkup"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6487-504X","authenticated-orcid":false,"given":"Atsushi","family":"Nakayama","sequence":"first","affiliation":[{"name":"Division of Research and Development for Minimally Invasive Treatment Cancer Center, Keio University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7579-1316","authenticated-orcid":false,"given":"Motohiko","family":"Kato","sequence":"additional","affiliation":[{"name":"Center for Diagnostic and Therapeutic Endoscopy Keio University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiki","family":"Sakaguchi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"},{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine Nihon University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Kodashima","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine Teikyo University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ai","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Toho University Omori Medical Center  Tokyo 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