{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T19:13:45Z","timestamp":1765826025149,"version":"3.41.2"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T00:00:00Z","timestamp":1738195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cirrhosis is an irreversible stage of liver damage that decreases the ability of the liver to store and metabolize nutrients. Malnutrition is a common problem in patients with cirrhosis and increases the risk of mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study aimed to assess malnutrition and associated factors among patients with cirrhosis at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional study was conducted at Tikur Anbessa Specialized Hospital. All patients with cirrhosis who were admitted to the hospital from August to November were included. Royal Free Hospital Global Assessment tool (RFH\u2010GA) was used to assess nutritional status. Data were entered in Epi\u2010data software version 4.6.0.2 and analyzed with STATA version 17\/MP. Ordinal logistic regression analysis was fitted to determine factors associated with nutritional status. Statistical significance was declared at <jats:italic>p<\/jats:italic> value &lt;\u20090.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of moderate malnutrition and severe malnutrition were 36.67% and 14.29%, respectively. Patients with ascites were five times at a higher risk of being severely malnourished (AOR\u2009=\u20095.08; 95% CI\u2009=\u20092.66\u20139.67). The odds of severe malnutrition decrease by 0.35 times for patients without a history of previous hospitalization (AOR\u2009=\u20090.35; 95% CI\u2009=\u20090.18\u20130.68). The odds of being in the higher category of nutritional status (severe malnutrition) are 10 times higher for patients with hepatic encephalopathy (AOR\u2009=\u200910.43; 95% CI\u2009=\u20094.66\u201323.31). As the level of creatinine blood urea nitrogen (Cr\u2010BUN) increases, the risk of malnutrition increases by 2.57 times (AOR\u2009=\u20092.57; 95% CI\u2009=\u20091.02\u20135.78).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Malnutrition is high among cirrhotic patients at Tikur Anbessa Specialized Hospital. Ascites, history of hospitalization, Cr\u2010BUN, and hepatic encephalopathy are significant predictors of malnutrition.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.70107","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T06:50:07Z","timestamp":1738306207000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Malnutrition and Associated Factors Among Patients With Cirrhosis at a Tertiary Care Center in Addis Ababa Ethiopia: An Ordinal Logistic Regression Analysis"],"prefix":"10.1002","volume":"9","author":[{"given":"Metages Damtie","family":"Melaku","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, College of Health Sciences Debre Tabor University  Debre Tabor Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aklog Almaw","family":"Yigzaw","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Health Sciences Debre Tabor University  Debre Tabor Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoseph Gebremedhin","family":"Kassie","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Debre Tabor Comprehensive Specialized Hospital  Debre Tabor Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mulugeta Wondmu","family":"Kedimu","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Health Sciences Debre Tabor University  Debre Tabor Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henok Bahru","family":"Wodajeneh","sequence":"additional","affiliation":[{"name":"Enchichi Hospital Oromia Health Bureau  Addis Ababa Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binyam Melese","family":"Getahun","sequence":"additional","affiliation":[{"name":"Eka Kotebe General Hospital, Ministry of Health  Addis Ababa Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denekew Tenaw","family":"Anley","sequence":"additional","affiliation":[{"name":"Department of Public Health, College of Health Sciences Debre Tabor University  Debre Tabor Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melaku Mekonen","family":"Agidew","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, College of Health Sciences Debre Tabor University  Debre Tabor Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8059-3576","authenticated-orcid":false,"given":"Edgeit Abebe","family":"Zewde","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, College of Health Sciences Debre Tabor University  Debre Tabor Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.09.014"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.909455"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2021.1912167"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214\u2010109X(18)30344\u20109"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/8740157"},{"key":"e_1_2_10_7_1","first-page":"1","article-title":"Nutrition Update in Hepatic Failure","author":"Krenitsky J.","year":"2014","journal-title":"Practical Gastroenterology"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2011.08.016"},{"issue":"2","key":"e_1_2_10_9_1","first-page":"65","article-title":"Malnutrition in Liver Cirrhosis:The Influence of Protein and Sodium","volume":"5","author":"Eghtesad S.","year":"2013","journal-title":"Middle East Journal of Digestive Diseases"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/fg.2009.000414"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29003"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hgmx.2015.04.003"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114520002366"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1590\/s0004-2803.201700000-28"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302514b.40"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/rco2.40"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12040893"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2020.12.013"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2021.e07362"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12999"},{"issue":"3","key":"e_1_2_10_21_1","first-page":"327","article-title":"Evaluation of Nutritional Status in Patients With Liver Cirrhosis. Validity and Prognostic Value of the Patient\u2010Generated Subjective Global Assessment","volume":"18","author":"Pentiuk N.","year":"2023","journal-title":"Przegl\u0105d Gastroenterologiczny"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.59779\/jiomnepal.1038"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.4172\/2167-0889.1000162"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(05)00531-8"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.06.024"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/489823"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13668-017-0216-8"},{"issue":"5","key":"e_1_2_10_28_1","first-page":"1382","article-title":"Factors Affecting the Outcome of Hospitalization Among Liver Cirrhosis Patients","volume":"35","author":"Irfan M.","year":"2019","journal-title":"Pakistan Journal of Medical Sciences"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-015-4015-z"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.5812\/hepatmon.99497"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc8855"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201020985\u2010z"}],"container-title":["JGH Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgh3.70107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T11:48:04Z","timestamp":1741002484000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jgh3.70107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,30]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1002\/jgh3.70107"],"URL":"https:\/\/doi.org\/10.1002\/jgh3.70107","archive":["Portico"],"relation":{},"ISSN":["2397-9070","2397-9070"],"issn-type":[{"type":"print","value":"2397-9070"},{"type":"electronic","value":"2397-9070"}],"subject":[],"published":{"date-parts":[[2025,1,30]]},"assertion":[{"value":"2024-05-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70107"}}