{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T18:30:43Z","timestamp":1783794643927,"version":"3.55.0"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:00:00Z","timestamp":1742774400000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2025,3]]},"abstract":"ABSTRACT<\/jats:title>Aims<\/jats:title>Patients with cirrhosis are susceptible to decompensation events, including ascites, variceal bleeding (VB), hepatic encephalopathy, or death after COVID\u201019 infection. Patients may experience post\u2010COVID condition (PCC) with multisystem involvement that persists for at least 2\u2009months.<\/jats:p><\/jats:sec>Methods<\/jats:title>Hospitalized patients with cirrhosis and COVID\u201019 between January 2021 and January 2023 were assessed for decompensation events and mortality and compared to a propensity\u2010matched cohort of cirrhosis and non\u2010COVID\u201019 sepsis. Both groups were followed for outcomes over 1\u2009year.<\/jats:p><\/jats:sec>Results<\/jats:title>Of 252 patients with Cirrhosis+ COVID\u201019 (73% men, aged 48.9\u2009\u00b1\u200913.7\u2009years, 31%\u2010diabetes, 44%\u2010hypertension, 35%\u2010alcohol\u2010associated, 34.5%\u2010metabolic dysfunction\u2010associated steatotic liver disease; MASLD), 72 (28.6%) died in hospital and 180 (71.4%) recovered, similar to Cirrhosis+ non\u2010COVID\u2010sepsis (58\/214, 27.1%). Finally,60 (33.3%) met criteria for PCC, 19 (10.5%) had no post COVID\u201019 sequelae and 101 (56.1%) patients died (N<\/jats:italic>\u2009=\u200945) or were lost to follow up (N<\/jats:italic>\u2009=\u200956). Late Mortality was higher in Cirrhosis+ COVID\u201019 than non\u2010COVID\u2010sepsis (56.1% vs. 35.3%, p<\/jats:italic>\u2009=\u20090.026). Patients with PCC were aged 47.6\u2009years, 63.3%\u2010men, Charlson Comorbidity Index >\u20094 (51.7%), 45%\u2010diabetes, 56.7%\u2010hypertension, with 33.3%, 23.3%, and 43.3% in Child\u2010Turcotte\u2010Pugh class A, B and C, respectively. PCC symptoms included persistent dyspnea (34, 43%), cognitive impairment (20, 25.3%), and anxiety (47, 59.4%). On multivariable analysis, predictors of the development of PCC were baseline MELDNa (HR 1.12, 95% CI: 1.05\u20131.17, p<\/jats:italic>\u2009<\u20090.001) and age (HR 0.9, 95% CI: 0.91\u20130.99, p<\/jats:italic>\u2009=\u20090.012). Predictors of mortality following COVID\u201019 recovery were MELDNa (HR 1.03, 95% CI: 1.01\u20131.05, p<\/jats:italic>\u2009=\u20090.008), age (HR 1.2, 95% CI: 1.1\u20131.5, p<\/jats:italic>\u2009=\u20090.002) and hypertension (HR 1.63, 95% CI: 1.07\u20132.49, p<\/jats:italic>\u2009=\u20090.025).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>COVID\u201019 is associated with long\u2010term mortality in cirrhosis even after recovery from respiratory infection. Long COVID is seen in a third of COVID\u201019 survivors in patients with cirrhosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.70142","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T23:16:16Z","timestamp":1743030976000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Post COVID<\/scp> Condition and Long\u2010Term COVID<\/scp>\u201019 Impact on Hepatic Decompensation and Survival in Cirrhosis: A Propensity Matched Observational Study"],"prefix":"10.1002","volume":"9","author":[{"given":"Prerna","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Hepatology Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2961-4148","authenticated-orcid":false,"given":"Madhumita","family":"Premkumar","sequence":"additional","affiliation":[{"name":"Department of Hepatology Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi Ranjan","family":"Guru","sequence":"additional","affiliation":[{"name":"Department of Hospital Administration Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anchal","family":"Sandhu","sequence":"additional","affiliation":[{"name":"Department of Hepatology Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamal","family":"Kajal","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Critical Care Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8567-1676","authenticated-orcid":false,"given":"Arka","family":"De","sequence":"additional","affiliation":[{"name":"Department of Hepatology Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahaj","family":"Rathi","sequence":"additional","affiliation":[{"name":"Department of Hepatology Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nipun","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Hepatology Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Taneja","sequence":"additional","affiliation":[{"name":"Department of Hepatology Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virendra","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Hepatology Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3590-2664","authenticated-orcid":false,"given":"Ajay Kumar","family":"Duseja","sequence":"additional","affiliation":[{"name":"Department of Hepatology Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,24]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15916"},{"issue":"5","key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1007\/s12072-020-10078-2","article-title":"Prevalence of Chronic Liver Disease in Patients With COVID\u201019 and Their Clinical Outcomes: A Systematic Review and Meta\u2010Analysis","volume":"14","author":"Kovalic A. 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