{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T15:41:14Z","timestamp":1776872474108,"version":"3.51.2"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,22]],"date-time":"2025-03-22T00:00:00Z","timestamp":1742601600000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Nearly half of the world population is infected by <jats:styled-content style=\"fixed-case\"><jats:italic>Helicobacter pylori<\/jats:italic><\/jats:styled-content> (<jats:styled-content style=\"fixed-case\"><jats:italic>H. pylori<\/jats:italic><\/jats:styled-content>). Bismuth\u2010containing quadruple therapy (BQT) has shown favorable outcomes. This study compares 10\u2010day and 14\u2010day BQT regimens to evaluate their efficacy, safety, and compliance rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched electronic databases from their inception until May 2024 to retrieve all randomized controlled trials (RCTs) that compared 10\u2010day and 14\u2010day BQT regimens for <jats:styled-content style=\"fixed-case\"><jats:italic>H. pylori<\/jats:italic><\/jats:styled-content> eradication. Meta\u2010analysis was performed using Review Manager 5.4. Dichotomous outcomes were compared using the risk ratio (RR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven RCTs and a total of 2424 patients were included in the meta\u2010analysis. There was no significant difference in the intention\u2010to\u2010treat eradication rate (RR 0.97; 95% CI 0.94, 1.01) and the per\u2010protocol eradication rate (RR 0.96; 95% CI 0.93, 1.00) between the 10\u2010day BQT and 14\u2010day BQT groups. Commonly reported adverse events in both groups were epigastric pain and discomfort, nausea, and vomiting. There was no significant difference in the risk of adverse events between the two groups (RR 0.85; 95% CI 0.70, 1.03). There was no significant difference in the compliance rate between the two groups (RR 1.02; 95% CI 1.00, 1.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The eradication rates, risk of adverse events, and compliance rates were comparable between the two groups. Future research comparing similar drug doses with larger sample sizes and longer patient follow\u2010ups can improve the quality of results.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.70143","type":"journal-article","created":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T17:02:35Z","timestamp":1742749355000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy and Safety of 10\u2010Day Versus 14\u2010Day Bismuth\u2010Containing Quadruple Therapy for <scp><i>Helicobacter pylori<\/i><\/scp> Eradication: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"9","author":[{"given":"Najam","family":"Gohar","sequence":"first","affiliation":[{"name":"Department of Medicine Ameer\u2010ud\u2010Din Medical College  Lahore Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoya","family":"Ejaz","sequence":"additional","affiliation":[{"name":"Department of Medicine Jinnah 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