{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:57:27Z","timestamp":1753869447973,"version":"3.41.2"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Lymphomas present a significant challenge in the field of gastrointestinal diseases, often being mistaken for other gastrointestinal tumors or inflammatory bowel disease conditions, causing clinical confusion. Early diagnosis plays a pivotal role in effective treatment. This case highlights the importance of recognizing lymphoproliferative disorders as a rare association of anti\u2010tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Presentation<\/jats:title><jats:p>A 41\u2010year\u2010old man with a 15\u2010year history of Crohn disease on long\u2010term therapy with adalimumab underwent a right hemicolectomy due to a semi\u2010circumferential lesion at the ileocecal valve causing near complete obstruction and severe anemia (Hgb 6.4\u2009g\/dL). Previous biopsies of the mass showed an Epstein Barr Virus\u2010positive (EBV+) classic Hodgkin lymphoma (CHL) in Crohn disease. At resection, the lymphoma showed transmural involvement of the ileum and regional lymph nodes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Primary intestinal CHL comprises less than 5% of gastrointestinal lymphomas; CHL arising in the context of Crohn disease is even more rare. Most lymphomas associated with inflammatory bowel disease and\/or immunosuppression are non\u2010Hodgkin type. In this case, the long\u2010term treatment with anti\u2010TNF\u2010\u03b1 and EBV positivity suggested an iatrogenic immunodeficiency\u2010associated lymphoma, an emerging group of lymphoproliferative disorders associated with the increased use of immunosuppressants.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.70154","type":"journal-article","created":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T05:48:37Z","timestamp":1744955317000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Primary Gastrointestinal <scp>EBV<\/scp>\u2010Associated Classical Hodgkin Lymphoma in Crohn Disease on Anti\u2010<scp>TNF<\/scp>\u2010\u03b1 Therapy: A Rare Association"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9603-6731","authenticated-orcid":false,"given":"Katrina","family":"Collins","sequence":"first","affiliation":[{"name":"Department of Pathology Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ani","family":"Toklu","sequence":"additional","affiliation":[{"name":"Department of Pathology Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nishi","family":"Dave","sequence":"additional","affiliation":[{"name":"Department of Pathology Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hector","family":"Mesa","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Maryland School of Medicine and Medical Center  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.04.072"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjy096"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00247"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10679"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-019-01145-8"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.085852"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27402"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70294-5"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022015851"},{"volume-title":"World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues","year":"2024","author":"Swerdlow S. 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