{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:57:26Z","timestamp":1753869446196,"version":"3.41.2"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T00:00:00Z","timestamp":1744156800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Portal myofibroblasts (PMF) are known to be critical in bile duct injury, but their role in liver fibrogenesis remains underexplored. Thy\u20101, an adhesion molecule detected as soluble Thy\u20101 (sThy\u20101) in serum, is primarily expressed by portal myofibroblasts (PMF) and, to a lesser extent, hepatic stellate cells (HSC), serving as a marker for myofibroblast activity in liver pathology. This study aimed to elucidate the correlation between Thy\u20101 expression in liver histology and sThy\u20101 levels in serum with the degree of liver fibrosis in patients with primary biliary cholangitis (PBC) and metabolic dysfunction\u2010associated steatotic liver disease (MASLD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Liver histology samples were stained for Thy\u20101, and sThy\u20101 was measured using an enzyme\u2010linked immunosorbent assay (ELISA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In patients with PBC and MASLD, an association between portal Thy\u20101 expression and the extent of fibrosis was observed. Notably, while sinusoidal Thy\u20101 expression aligned with fibrosis severity in PBC (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), this association was not statistically significant in MASLD (<jats:italic>p<\/jats:italic>\u2009=\u20090.059). Moreover, variations in soluble Thy\u20101 levels paralleled the progression from mild to advanced fibrosis stages in PBC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Thy\u20101 expression levels were associated with the severity of fibrosis, which could support its role in monitoring the presence and activity of myofibroblasts in liver diseases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.70155","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T06:06:41Z","timestamp":1744265201000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the Role of Thy\u20101 and Its Soluble Form Regarding Fibrosis Severity in Primary Biliary Cholangitis and Metabolic Dysfunction\u2010Associated Fatty Liver Disease"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5027-3432","authenticated-orcid":false,"given":"Mirjam","family":"Kolev","sequence":"first","affiliation":[{"name":"Department of Visceral Surgery and Medicine, Inselspital Bern University Hospital, University of Bern  Bern Switzerland"},{"name":"Department for BioMedical Research, Visceral Surgery and Medicine University of Bern  Bern Switzerland"},{"name":"Graduate School for Health Sciences University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahel","family":"B\u00fctikofer","sequence":"additional","affiliation":[{"name":"Department of Visceral Surgery and Medicine, Inselspital Bern University Hospital, University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja","family":"Saalbach","sequence":"additional","affiliation":[{"name":"Departement of Dermatology, Venerology and Allergology University of Leipzig Medical Center  Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Kollert","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Bern University Hospital, University of Bern  Bern Switzerland"},{"name":"Department of Rheumatology University Hospital Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Montani","sequence":"additional","affiliation":[{"name":"Institute of Tissue Medicine and Pathology University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasser","family":"Semmo","sequence":"additional","affiliation":[{"name":"Department of Visceral Surgery and Medicine, Inselspital Bern University Hospital, University of Bern  Bern Switzerland"},{"name":"Department for BioMedical Research, Visceral Surgery and Medicine University of Bern  Bern 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