{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:46Z","timestamp":1792108846522,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background &amp; Aims<\/jats:title>\n                    <jats:p>Alcoholic hepatitis (AH) is a severe manifestation of alcoholic liver disease with high morbidity and mortality. This study used the 2016\u20132020 National Readmission Database to investigate how obesity influences AH outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adult hospitalizations were categorized as those without obesity, Class 1 obesity (BMI 30\u201334.9), Class 2 obesity (BMI 35\u201339.9), or Class 3 obesity (BMI \u2265\u200940). We compared mortality, complications, and resource utilization across these groups using regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 82\u2009367 AH admissions, 4.09% had Class 1 obesity, 2.73% had Class 2 obesity, and 4.02% had Class 3 obesity. After adjusting for confounders, Class 3 obesity was associated with higher odds of mortality (Odds ratio OR\u2009=\u20091.74; 95% CI: 1.40\u20132.17;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01), septic shock (OR\u2009=\u20092.27; 95% CI: 1.60\u20133.22;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01), hepatic encephalopathy (OR\u2009=\u20092.53; 95% CI: 1.15\u20135.56;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02), and intensive care unit (ICU) admission (OR\u2009=\u20091.93; 95% CI: 1.57\u20132.36;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). All obesity classes had increased associations with hepatorenal syndrome. No significant differences emerged for spontaneous bacterial peritonitis or variceal bleeding. Resource utilization rose with increasing obesity severity, with Class 3 obesity having a 1.84\u2010day longer adjusted length of stay (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) and an additional $20\u2009174 in total hospitalization charges (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) compared with hospitalizations without obesity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Class 3 obesity conferred the greatest burden of mortality, complications, and healthcare costs among hospitalizations with AH. Further research is warranted to clarify the intricate interplay between obesity and AH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jgh3.70166","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T09:20:33Z","timestamp":1744708833000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Influence of Obesity Class on Clinical Outcomes in Alcoholic Hepatitis: A National Cohort Study of Mortality, Complications, and Resource Use"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1155-7931","authenticated-orcid":false,"given":"Ali","family":"Jaan","sequence":"first","affiliation":[{"name":"Division of Internal Medicine Rochester General Hospital  Rochester USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa Suhail","family":"Najim","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine Unity Hospital  Rochester USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umer","family":"Farooq","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Saint Louis University  Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Dhawan","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine Gian Sagar Medical College and Hospital  Patiala district India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Nawaz","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine Nishtar Medical University  Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinay","family":"Jahagirdar","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Virginia Commonwealth University  Richmond USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5546-9197","authenticated-orcid":false,"given":"Hassam","family":"Ali","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology East Carolina University\/ECU Health Medical Center  Greenville USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushil","family":"Ahlawat","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology SUNY Downstate Health Sciences University  Brooklyn USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41395-018-0182-9"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15376"},{"issue":"2","key":"e_1_2_11_4_1","first-page":"161","article-title":"Alcoholic Hepatitis","volume":"6","author":"Testino G.","year":"2013","journal-title":"Journal of Medicine and Life"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0192393"},{"key":"e_1_2_11_6_1","unstructured":"OECD \u201cOverweight and Obesity Among Adults \u201d2017."},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.113905"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.213553"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29631"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws252"},{"key":"e_1_2_11_11_1","volume-title":"The Healthcare Cost and Utilization Project","author":"Overview of the Nationwide Readmissions Database (NRD)","year":"2022"},{"key":"e_1_2_11_12_1","volume-title":"Report of a WHO Consultation","author":"Obesity: preventing and managing the global epidemic","year":"2000"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.16388"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2024.2310161"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000520"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13679-014-0129-4"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-020-06056-1"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c1240"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.03.046"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12427"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1210\/jendso\/bvab048.069"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24418"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/HC9.0000000000000160"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v28.i34.5036"},{"key":"e_1_2_11_25_1","volume-title":"Prevalence of Overweight, Obesity, and Severe Obesity Among Adults Aged 20 and Over: United States","author":"Fryar C. 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