{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:56:34Z","timestamp":1753869394588,"version":"3.41.2"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The association between gastroesophageal reflux disease (GERD) and hypertensive disorders in pregnancy (HDP) is unclear. A bidirectional Mendelian randomization (MR) analysis was conducted to investigate the causal association between GERD and HDP using the public databases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Four methods were applied in our MR analysis, including the inverse variance weighting (IVW), MR\u2013Egger, weighted median, and weighted mode. A series of sensitivity analyses were conducted to affirm the stability and reliability of the results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>IVW analysis showed a potential causal association between GERD and pre\u2010eclampsia (PE) (OR\u2009=\u20091.20, <jats:italic>p<\/jats:italic>\u2009=\u20090.048), as well as gestational hypertension (GH) (OR\u2009=\u20091.26, <jats:italic>p<\/jats:italic>\u2009=\u20090.008). The other three methods, including MR\u2013Egger, weighted median, and weighted mode, yielded consistent results. Heterogeneity existed between GERD and PE (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), as well as GH (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) in sensitivity analyses. However, there was no pleiotropy in MR analysis results (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). Leave\u2010one\u2010out analysis indicated that none of the SNPs had a potential impact on IVW results. In the reverse MR analysis, there is no causal effect of HDP on GERD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results demonstrated that GERD exhibited a causal relationship with a high risk of HDP, which contributed to the ongoing discourse of GERD in the etiology of HDP.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.70176","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T09:09:07Z","timestamp":1750324147000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Genetic Evidence of Association Between Gastroesophageal Reflux Disease and Hypertensive Disorders in Pregnancy"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4002-9835","authenticated-orcid":false,"given":"Qiong","family":"Li","sequence":"first","affiliation":[{"name":"Jinan University  Guangzhou China"},{"name":"The First People's Hospital of Chenzhou  Chenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yajing","family":"Pang","sequence":"additional","affiliation":[{"name":"Wuxi School of Medicine Jiangnan University  Wuxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaoyan","family":"Yue","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Hospital of Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenyang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Jinan University  Guangzhou China"},{"name":"The First People's Hospital of Chenzhou  Chenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongzhu","family":"Lei","sequence":"additional","affiliation":[{"name":"Jinan University  Guangzhou China"},{"name":"The First People's Hospital of Chenzhou  Chenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Hospital of Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,19]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_11_2_1","DOI":"10.1038\/hr.2016.126"},{"doi-asserted-by":"publisher","key":"e_1_2_11_3_1","DOI":"10.1016\/j.preghy.2018.05.004"},{"doi-asserted-by":"publisher","key":"e_1_2_11_4_1","DOI":"10.1097\/AOG.0000000000002114"},{"doi-asserted-by":"publisher","key":"e_1_2_11_5_1","DOI":"10.1016\/S2214-109X(14)70227-X"},{"doi-asserted-by":"publisher","key":"e_1_2_11_6_1","DOI":"10.1097\/AOG.0000000000003892"},{"doi-asserted-by":"publisher","key":"e_1_2_11_7_1","DOI":"10.4297\/najms.2011.3142"},{"doi-asserted-by":"publisher","key":"e_1_2_11_8_1","DOI":"10.1590\/s0004-2803.2017v54n1-08"},{"doi-asserted-by":"publisher","key":"e_1_2_11_9_1","DOI":"10.1097\/MCG.0000000000000933"},{"doi-asserted-by":"publisher","key":"e_1_2_11_10_1","DOI":"10.1371\/journal.pone.0047575"},{"doi-asserted-by":"publisher","key":"e_1_2_11_11_1","DOI":"10.1161\/HYPERTENSIONAHA.116.08408"},{"doi-asserted-by":"publisher","key":"e_1_2_11_12_1","DOI":"10.1161\/HYPERTENSIONAHA.117.09741"},{"doi-asserted-by":"publisher","key":"e_1_2_11_13_1","DOI":"10.2147\/CLEP.S382303"},{"doi-asserted-by":"publisher","key":"e_1_2_11_14_1","DOI":"10.1055\/s-0040-1713864"},{"doi-asserted-by":"publisher","key":"e_1_2_11_15_1","DOI":"10.1093\/hmg\/ddu328"},{"doi-asserted-by":"publisher","key":"e_1_2_11_16_1","DOI":"10.1101\/cshperspect.a040501"},{"doi-asserted-by":"publisher","key":"e_1_2_11_17_1","DOI":"10.1001\/jama.2021.18236"},{"doi-asserted-by":"publisher","key":"e_1_2_11_18_1","DOI":"10.1136\/gutjnl-2020-323906"},{"doi-asserted-by":"publisher","key":"e_1_2_11_19_1","DOI":"10.1093\/ije\/dyq151"},{"doi-asserted-by":"publisher","key":"e_1_2_11_20_1","DOI":"10.1016\/S0953-6205(02)00090-0"},{"doi-asserted-by":"publisher","key":"e_1_2_11_21_1","DOI":"10.1097\/MD.0000000000004089"},{"doi-asserted-by":"publisher","key":"e_1_2_11_22_1","DOI":"10.1186\/s12876-019-0950-z"},{"doi-asserted-by":"publisher","key":"e_1_2_11_23_1","DOI":"10.1111\/nmo.14234"},{"issue":"6","key":"e_1_2_11_24_1","first-page":"507","article-title":"Gastro\u2010Esophageal Reflux Disease (Part I). 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