{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:56:34Z","timestamp":1753869394588,"version":"3.41.2"},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2025,5]]},"abstract":"ABSTRACT<\/jats:title>Introduction<\/jats:title>Clostridioides difficile infection (CDI) is a significant cause of antibiotic\u2010associated diarrhea with high morbidity and mortality, particularly in cases of fulminant disease. Fecal microbiota transplantation (FMT) has demonstrated efficacy in treating severe and refractory CDI, typically administered via colonoscopy. However, in cases complicated by toxic megacolon, alternative methods of FMT delivery may be necessary.<\/jats:p><\/jats:sec>Case Report<\/jats:title>This case report describes a 46\u2010year\u2010old female with cirrhosis and fulminant CDI complicated by toxic megacolon. Due to the patient's hemodynamic instability and contraindications to endoscopic FMT delivery, a novel approach of nasogastric FMT administration was utilized. The patient received a combination of enema\u2010delivered and nasogastric FMT alongside standard antibiotic therapy. This approach resulted in rapid clinical improvement, with resolution of toxic megacolon, normalization of inflammatory markers, and avoidance of colectomy.<\/jats:p><\/jats:sec>Discussion<\/jats:title>This report highlights the successful use of nasogastric FMT in a patient with fulminant CDI, offering a potential alternative delivery route when colonoscopic administration is contraindicated. To our knowledge, this is the first reported case of nasogastric FMT successfully resolving C. difficile<\/jats:italic>\u2010associated toxic megacolon.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.70177","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T06:35:06Z","timestamp":1747204506000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Nasogastric Delivery of Fecal Microbiota Transplantation for the Treatment of Fulminant Clostridioides difficile<\/i> Infection: A Case Report"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9735-0618","authenticated-orcid":false,"given":"Amitjeet","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Medicine Lyell McEwin Hospital Elizabeth South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1568-5896","authenticated-orcid":false,"given":"Edward","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Lyell McEwin Hospital Elizabeth South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5551-8592","authenticated-orcid":false,"given":"Aashish","family":"Maurya","sequence":"additional","affiliation":[{"name":"Department of Medicine Lyell McEwin Hospital Elizabeth South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arvind","family":"Rajagopalan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Lyell McEwin Hospital Elizabeth South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879\u2010021\u201006147\u2010y"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep37865"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.13027"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14201"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010\u2010012\u20100307\u20109"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl14152"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MJT.0000000000000062"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD013871.pub2"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2016.98"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/NNR.0b013e3181c3ba05"}],"container-title":["JGH Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgh3.70177","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T07:43:36Z","timestamp":1748418216000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jgh3.70177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1002\/jgh3.70177"],"URL":"https:\/\/doi.org\/10.1002\/jgh3.70177","archive":["Portico"],"relation":{},"ISSN":["2397-9070","2397-9070"],"issn-type":[{"type":"print","value":"2397-9070"},{"type":"electronic","value":"2397-9070"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"2024-09-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70177"}}