{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:56:28Z","timestamp":1753869388836,"version":"3.41.2"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Medication adherence is critical in 5\u2010aminosalicylate therapy for patients with ulcerative colitis. Patients with a history of previous medication self\u2010discontinuation may continue to have low adherence due to the influence of inappropriate disease awareness. This study aimed to determine the association between the history of previous medication self\u2010discontinuation and current adherence to 5\u2010aminosalicylates in patients with ulcerative colitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>This cross\u2010sectional study was conducted in Japan from 2021 to 2024. A self\u2010administered questionnaire was used in 228 patients with ulcerative colitis who were taking 5\u2010aminosalicylates. We defined adherence as consumption of \u2265\u200980% of the prescribed dose. Patients with a history of previous medication self\u2010discontinuation were defined as having discontinued medication at least once in the past by their own judgment. The current adherence rate to 5\u2010aminosalicylates in this study was 92.9% (212\/228). The proportion of patients with a history of previous medication self\u2010discontinuation was 7.8% (18\/228). History of previous medication self\u2010discontinuation (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), younger age (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and once\u2010daily 5\u2010aminosalicylates regimen (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) were inversely associated with current adherence to 5\u2010aminosalicylates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>History of previous medication self\u2010discontinuation was inversely associated with current adherence to 5\u2010aminosalicylates among patients with ulcerative colitis. The results of this study suggest that determining the history of previous medication self\u2010discontinuation may be a valuable tool in assessing current adherence to 5\u2010aminosalicylates, which can be cumbersome.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.70181","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T05:28:13Z","timestamp":1747805293000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["History of Previous Medication Self\u2010Discontinuation Predicts the Current Adherence to 5\u2010Aminosalicylates in Patients With Ulcerative Colitis"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2133-6569","authenticated-orcid":false,"given":"Shogo","family":"Kitahata","sequence":"first","affiliation":[{"name":"Gastroenterology Center Ehime Prefectural Central Hospital  Matsuyama Ehime 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