{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:46:35Z","timestamp":1792525595556,"version":"4.5.0"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>It seems that the presence of tissue eosinophils in IBD patients can provide more information to predict the prognosis and outcome of the disease, especially in children. However, there is very limited evidence in this regard. Here, we designed a retrospective study to investigate the effect of tissue eosinophils on children with IBD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed 73 pediatric patients with IBD with a retrospective study design who underwent measurement of fecal calprotectin (FC) and colonoscopy. IBD patients with and without tissue eosinophils diagnosed according to guidelines were compared in terms of disease activity, clinical symptoms, and other clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the present study, 37 patients without and 36 patients with tissue eosinophilia were investigated. This study indicated a significant relationship between the mean eosinophil and Mayo score as the severity of the UC disease based on colonoscopy. However, the findings of the present study did not report any difference between the two groups in terms of disease severity markers and disease activity (base on pediatric ulcerative colitis activity index (PUCAI) for UC and the pediatric Crohn's disease activity index (PCDAI) for CD). The findings showed that the mean eosinophilia in cecum\/ascending and rectum\/sigmoid colon is significantly higher in pediatric IBD with tissue eosinophilia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although no significant finding was found between tissue eosinophil and disease outcomes it seems that there is a significant linear relationship between mean tissue eosinophil and Mayo score.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.70187","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T11:11:20Z","timestamp":1747739480000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of Tissue Eosinophilia on the Disease Outcome of Pediatric With Inflammatory Bowel Disease (<scp>IBD<\/scp>)"],"prefix":"10.1002","volume":"9","author":[{"given":"Arefeh","family":"Zahmatkesh","sequence":"first","affiliation":[{"name":"School of Medicine Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6723-7112","authenticated-orcid":false,"given":"Mohammad Hassan","family":"Sohouli","sequence":"additional","affiliation":[{"name":"School of Medicine Shahid Beheshti University of Medical Sciences  Tehran Iran"},{"name":"Pediatric Gastroenterology and Hepatology Research Center, Pediatrics Centre of Excellence, Children's Medical Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reyhane","family":"Zojaji","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Hepatology Research Center, Pediatrics Centre of Excellence, Children's Medical Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam Kazemi","family":"Aghdam","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine Shahid Beheshti University of Medical Science  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pejman","family":"Rohani","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Hepatology Research Center, Pediatrics Centre of Excellence, Children's Medical Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7247238"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2022\u2010058037"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.12.282"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31828f21b4"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j2083"},{"issue":"10","key":"e_1_2_10_7_1","first-page":"2429","article-title":"Eosinophils and IL\u201033 Perpetuate Chronic Inflammation and Fibrosis in a Pediatric Population With Stricturing Crohn's Ileitis","volume":"21","author":"Masterson J. 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