{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:43:12Z","timestamp":1792658592796,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Estimated plasma volume status (ePVS) correlates with intravascular congestion and prognosis in patients with heart failure. The ePVS relationship with invasive hemodynamic profiling and clinical outcomes in patients with liver cirrhosis (LC) remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This single\u2010center retrospective cohort study included LC patients who underwent right heart catheterization (RHC) between 2018 and 2023. Estimated plasma volume status (ePVS) was calculated using the Strauss\u2010derived Duarte formula, with patients classified into high (&gt;\u20095.5%) and low\u2010ePVS (\u2264\u20095.5%) groups. Cox\u2010multivariable analysis was used to determine if ePVS was associated with all\u2010cause mortality within 1\u2009year post\u2010RHC among transplant\u2010free patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 353 patients with LC (median age 59\u2009years, 59% male, 45% Caucasian, and 29% African American), 79% were classified into the high\u2010ePVS group. Compared to the low\u2010ePVS group, the high\u2010ePVS group had significantly higher right atrial pressure (9 vs. 6\u2009mmHg, <jats:italic>p<\/jats:italic>\u2009=\u20090.01), pulmonary arterial wedge pressure (14 vs. 11\u2009mmHg, <jats:italic>p<\/jats:italic>\u2009=\u20090.014), cardiac output (9.8 vs. 6.4\u2009L\/min, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), and cardiac index (5 vs. 3.1\u2009L\/min\/m<jats:sup>2<\/jats:sup>, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Additionally, the high\u2010ePVS group exhibited a higher prevalence of cirrhosis\u2010related complications, including ascites, splenomegaly, and varices, and a greater likelihood of receiving orthotopic liver transplantation within 1\u2009year (38% vs. 11%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Among transplant\u2010free patients, ePVS was independently associated with all\u2010cause mortality at 1\u2009year (HR 1.15, 95% CI: 1.00\u20131.32, <jats:italic>p<\/jats:italic>\u2009=\u20090.048).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study demonstrated that ePVS was associated with intravascular congestion, hyperdynamic circulation, and cirrhosis complications. Furthermore, ePVS was independently associated with all\u2010cause mortality among transplant\u2010free LC patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.70195","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T11:25:28Z","timestamp":1748863528000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association of Estimated Plasma Volume Status With Invasive Hemodynamics and All\u2010Cause Mortality in Patients With Liver Cirrhosis"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6831-9912","authenticated-orcid":false,"given":"Esteban","family":"Kosak Lopez","sequence":"first","affiliation":[{"name":"Department of Medicine; Jefferson Einstein Philadelphia Hospital Sidney Kimmel Medical College  Philadelphia Pennsylvania 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Hepatology Division NYU Grossman School of Medicine  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Malin","sequence":"additional","affiliation":[{"name":"Department of Medicine; Jefferson Einstein Philadelphia Hospital Sidney Kimmel Medical College  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul","family":"Leguizamon","sequence":"additional","affiliation":[{"name":"Department of Medicine; Jefferson Einstein Philadelphia Hospital Sidney Kimmel Medical College  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara A.","family":"John","sequence":"additional","affiliation":[{"name":"Department of Medicine; Jefferson Einstein Philadelphia Hospital Sidney Kimmel Medical College  Philadelphia Pennsylvania 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