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This case report details an instance of Cemiplimab\u2010induced colitis resulting in hypovolemic shock in a patient with cutaneous squamous cell carcinoma (cSCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Presentation<\/jats:title><jats:p>An 83\u2010year\u2010old male veteran with a complex history of scalp squamous cell carcinoma, treated initially with excision and radiation, experienced recurrence necessitating Cemiplimab therapy. One year post\u2010initiation, the patient presented with severe diarrhea, leading to hypovolemic shock and acute renal failure. Initial tests ruled out infectious causes. Endoscopic evaluation revealed inflammatory mucosal changes in the sigmoid colon, and histopathology confirmed active colitis. The patient responded well to high\u2010dose prednisone, with rapid improvement in symptoms, leading to a transfer to a lower level of care.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cemiplimab, approved for advanced cSCC, fulfills a crucial therapeutic need but is associated with immune\u2010related adverse events, including severe colitis. Management of such cases requires early endoscopy and corticosteroid therapy, which can significantly improve outcomes. This report underscores the importance of vigilant monitoring for gastrointestinal symptoms in patients undergoing ICI therapy and prompt intervention to mitigate severe complications.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.70198","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T11:44:46Z","timestamp":1749815086000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cemiplimab\u2010Induced Colitis Causing Hypovolemic Shock: A Case Report and Literature Review"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2311-6666","authenticated-orcid":false,"given":"Saeed S.","family":"Graham","sequence":"first","affiliation":[{"name":"Brody School of Medicine, Department of Internal Medicine East Carolina University  Greenville North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kena 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