{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T17:24:07Z","timestamp":1776705847414,"version":"3.51.2"},"reference-count":50,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to determine the prevalence of <jats:styled-content style=\"fixed-case\"><jats:italic>Helicobacter pylori<\/jats:italic><\/jats:styled-content> in relation to endoscopic and histopathology features and to find out the correlation between the two diagnostic methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Gastroduodenal biopsy specimens were collected from 475 dyspeptic outpatients who attended the Department of Gastroenterology in reference hospitals in Cameroon. The study was approved by the local and national ethical committees on human health research in Cameroon. Informed consent was obtained from all subjects before inclusion. A full endoscopic evaluation of the esophagus, stomach, and duodenum was performed in all patients. Biopsy samples were collected from each participant for <jats:styled-content style=\"fixed-case\"><jats:italic>H. pylori<\/jats:italic><\/jats:styled-content> detection using histology and rapid urease test. Hematoxylin and eosin stain was used for histomorphological features examination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\"><jats:italic>Helicobacter pylori<\/jats:italic><\/jats:styled-content> was found in 57.89% of the dyspeptic outpatients. In endoscopy, 40.00% of our patients had gastritis, of which 58.42% were <jats:styled-content style=\"fixed-case\"><jats:italic>H. pylori<\/jats:italic><\/jats:styled-content> infected. Erythematous\u2010exudative gastritis was the most common gastritis type (46.00%) and also the most common gastritis type found among <jats:styled-content style=\"fixed-case\"><jats:italic>H. pylori<\/jats:italic><\/jats:styled-content>\u2010infected subjects (43.1%). Histologically, chronic gastritis was the most common histological finding recorded (46.11%) and the abnormality with the highest rate of <jats:styled-content style=\"fixed-case\"><jats:italic>H. pylori<\/jats:italic><\/jats:styled-content> infection (44.00%). The highest rate of <jats:styled-content style=\"fixed-case\"><jats:italic>H. pylori<\/jats:italic><\/jats:styled-content> infection was found among patients with moderate neutrophil activity (46.18%). Gastritis types were significantly correlated with histological findings (<jats:italic>p<\/jats:italic>\u2009=\u20090.016). Endoscopic findings were significantly correlated with neutrophil activity (<jats:italic>p<\/jats:italic>\u2009=\u20090.0005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The current poor correlation observed between endoscopy and histology findings emphasizes the role of histology in the diagnosis of gastroduodenal pathological features in dyspeptic patients in our context.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.70222","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T06:03:44Z","timestamp":1754546624000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Conventional Upper\u2010Intestinal Endoscopy Value in Predicting Histopathological Features Related to <scp><i>Helicobacter pylori<\/i><\/scp> Infection: A Comparative Study Between Endoscopy and Histology Findings Among Dyspeptic Outpatients in Cameroon"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6447-1413","authenticated-orcid":false,"given":"Laure Brigitte Kouitcheu","family":"Mabeku","sequence":"first","affiliation":[{"name":"Medical Microbiology Laboratory, Department of Microbiology, Faculty of Science University of Yaound\u00e9 I  Yaound\u00e9 Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lionel Danny Tali","family":"Nguefak","sequence":"additional","affiliation":[{"name":"Microbiology and Pharmacology Laboratory, Department of Biochemistry, Faculty of Science University of Dschang  Dschang Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghislaine Florice Faujo","family":"Nintewoue","sequence":"additional","affiliation":[{"name":"Microbiology and Pharmacology Laboratory, Department of Biochemistry, Faculty of Science University of Dschang  Dschang Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5260-6595","authenticated-orcid":false,"given":"Stanley Ngimgoh","family":"Ngemeshe","sequence":"additional","affiliation":[{"name":"Microbiology and Pharmacology Laboratory, Department of Biochemistry, Faculty of Science University of Dschang  Dschang Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jude\u2010Marcel Nzoume Nsope","family":"Mengang","sequence":"additional","affiliation":[{"name":"Regional Hospital Bafoussam  Bafoussam Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghislaine","family":"Ngatcha","sequence":"additional","affiliation":[{"name":"Centre M\u00e9dicale la Cath\u00e9drale  Yaound\u00e9 Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carole Marlyse Menzy","family":"Moungo\u2010Ndjole","sequence":"additional","affiliation":[{"name":"General Hospital Yaound\u00e9  Yaound\u00e9 Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Talla","sequence":"additional","affiliation":[{"name":"General Hospital Yaound\u00e9  Yaound\u00e9 Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2015.158"},{"key":"e_1_2_11_3_1","first-page":"206","article-title":"Detection of Helicobacter pylori in Stool Specimens: Comparative Evaluation of Nested PCR and Antigen Detection","volume":"2","author":"Mishra S.","year":"2008","journal-title":"Journal of Infection in Developing Countries"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302084"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2005.00341.x"},{"key":"e_1_2_11_6_1","first-page":"52","article-title":"Assessment of Selected Tests in Diagnostics of \n                     Helicobacter pylori\n                   Infections","volume":"19","author":"Iwanczak F.","year":"2005","journal-title":"Polski Merkuriusz Lekarski"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S14555"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00433-13"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.9"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g3174"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-015-0479-y"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.15761\/GHE.1000211"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-011-1703-1"},{"key":"e_1_2_11_14_1","first-page":"207","article-title":"Working Party Report to the World Congresses of Gastroenterology, Sydney. 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