{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:53:24Z","timestamp":1788951204904,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:00:00Z","timestamp":1755475200000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>We previously reported that telomerase activator <jats:styled-content style=\"fixed-case\"><jats:italic>Centella asiatica<\/jats:italic><\/jats:styled-content> (CA) can normalize the crypt structure of human colonic organoids in an ulcerative colitis (UC) model. Therefore, we aimed to evaluate the safety and efficacy of CA for UC in a clinical trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Ten patients with mild UC were recruited. Patients received 500\u2009mg of oral CA extract tablets once daily for 12\u2009weeks. Safety and efficacy were monitored based on clinical manifestations, biomarkers, endoscopic findings, histopathological findings, and telomere length. Among 10 patients, one patient withdrew due to the relapse of UC. No adverse events were identified during the medication in the remaining nine patients. One patient showed a Partial Mayo Score (pMayo) decrease from 1 to 0, while the remaining eight pMayo scores remained at 0 before and after treatment. CRP, ESR, and leucine\u2010rich alpha 2 glycoprotein (LRG) levels remained unchanged throughout treatment. Two patients showed endoscopic improvement. The other two patients showed histological improvement. Among five patients, relative telomere length of the rectum remained unchanged by treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CA is safe for patients with UC. Longer treatment durations and larger participant pools are required to assess CA efficacy on histological healing in the future.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.70258","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T09:21:32Z","timestamp":1755508892000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Clinical Trial to Evaluate the Safety and Efficacy of <scp><i>Centella asiatica<\/i><\/scp> for Ulcerative Colitis"],"prefix":"10.1002","volume":"9","author":[{"given":"Xiangning","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Institute of Medicine University of Tsukuba  Tsukuba Japan"},{"name":"Graduate School of Comprehensive Human Sciences University of Tsukuba  Tsukuba 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