{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T09:10:19Z","timestamp":1756285819922,"version":"3.44.0"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Adherence to 5\u2010aminosalicylic acid (5\u2010ASA), an anchor drug for ulcerative colitis (UC), affects remission maintenance. This study aimed to investigate the current status of adherence to 5\u2010ASA and identify the factors associated with adherence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled UC patients whose primary maintenance therapy was oral 5\u2010ASA at our hospital between January 2017 and December 2018. The adherence status was examined using a questionnaire survey. Various factors, including patient background and disease activity, were also analyzed to identify those related to adherence. A second questionnaire with the same content was performed 1\u2009year after the initial survey for comparison.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 297 patients with UC answered the first questionnaire, of which 278 answered the second questionnaire. Complete adherence rates at the time of the first and second questionnaires were 49.8% (148\/297) and 55.8% (155\/278), respectively. Full\u2010time employment (<jats:italic>p<\/jats:italic>\u2009=\u20090.00893), eating one or two meals per day (<jats:italic>p<\/jats:italic>\u2009=\u20090.00641), and multiple daily doses (<jats:italic>p<\/jats:italic>\u2009=\u20090.0153) were significantly associated with lower adherence. The 119 patients who fully adhered to both the primary and secondary questionnaires had a significantly higher cumulative non\u2010relapse rate at 1\u2009year than those 159 who were not (85.7% vs. 76.1%, <jats:italic>p<\/jats:italic>\u2009=\u20090.0207).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>UC patients with high adherence to 5\u2010ASA showed a high rate of remission maintenance, so adherence should be improved by considering factors such as the number of medications taken, work status, and dietary habits.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.70259","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T07:29:43Z","timestamp":1755761383000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prospective Questionnaire Survey on Adherence to Oral 5\u2010Aminosalicylic Acid in Patients With Ulcerative Colitis"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1716-7096","authenticated-orcid":false,"given":"Tsuyoshi","family":"Beppu","sequence":"first","affiliation":[{"name":"Inflammatory Bowel Disease Center, Fukuoka University Chikushi Hospital  Chikushino Fukuoka Japan"},{"name":"Department of Gastroenterology Matsusaka Chuo General Hospital  Matsusaka Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5493-5675","authenticated-orcid":false,"given":"Fumihito","family":"Hirai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Fukuoka University Faculty of Medicine  Fukuoka Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3400-9172","authenticated-orcid":false,"given":"Kensei","family":"Ohtsu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Fukuoka University Chikushi Hospital  Chikushino Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Kishi","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center, Fukuoka University Chikushi Hospital  Chikushino Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teruyuki","family":"Takeda","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center, Fukuoka University Chikushi Hospital  Chikushino Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeyoshi","family":"Yasukawa","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center, Fukuoka University Chikushi Hospital  Chikushino Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1967-5169","authenticated-orcid":false,"given":"Noritaka","family":"Takatsu","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease 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