{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:17:37Z","timestamp":1790223457307,"version":"4.1.0"},"reference-count":10,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T00:00:00Z","timestamp":1759622400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>While Western real\u2010world studies have demonstrated the therapeutic effect of upadacitinib in Crohn's disease (CD), data on Asian populations are scarce, and no real\u2010world data from Japan have been reported. Therefore, this study aimed to assess the induction efficacy and safety of upadacitinib in Japanese patients with active CD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included CD patients who initiated upadacitinib at 10 inflammatory bowel disease (IBD) centers in Japan by December 2024. Clinical response, clinical remission, biomarker improvements, and adverse events were analyzed. Clinical response was defined as Crohn's Disease Activity Index (CDAI) &lt;\u2009150 or a decrease in CDAI (\u0394CDAI) &gt;\u200970, while clinical remission was defined as CDAI &lt;\u2009150.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 33 patients (16 males, 17 females) were included. The median age at upadacitinib administration was 40\u2009years, with a median disease duration of 9.3\u2009years. The median baseline values were 264 for CDAI, 14 for Simple Endoscopic Score for Crohn's Disease (SES\u2010CD), and 9.8\u2009mg\/L for serum C\u2010reactive protein (CRP). Corticosteroids were co\u2010administered in 11 patients (33.3%). Prior biologic therapy had been used in 25 patients (75.8%), including 7 patients with one biologic and 18 patients with two or more biologics. Extraintestinal manifestations were observed in 12 patients (36.4%), and perianal lesions in 15 patients (45.5%). All patients started upadacitinib at 45\u2009mg\/day. The clinical response, clinical remission, and steroid\u2010free clinical remission rates were 76.7%, 53.3%, and 36.7% by week 4; 83.3%, 63.3%, and 56.7% by week 8; and 86.7%, 70%, and 70% by week 12, respectively. Significant improvements in CDAI, serum CRP, and albumin were observed at week 12 or the last visit, compared to baseline. Improvement was observed in 66.7% of cases with extraintestinal manifestations and 46.7% of cases with perianal lesions. Adverse events occurred in 45.5% of patients, with acne being the most common (12.1%). No serious adverse events leading to death were reported. The continuation rate of upadacitinib at week 12 or the last visit was 93.3%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Upadacitinib demonstrated high induction efficacy and acceptable safety in Japanese patients with active CD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jgh3.70291","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T05:48:13Z","timestamp":1759729693000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Induction Efficacy and Safety of Upadacitinib for Active Crohn's Disease in Japanese Patients: A Multicenter Retrospective Study"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8595-9442","authenticated-orcid":false,"given":"Takuto","family":"Saiki","sequence":"first","affiliation":[{"name":"Department of Medicine and Clinical Science, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junji","family":"Umeno","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Science, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Matsuno","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Science, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Kawasaki","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Science, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0682-8971","authenticated-orcid":false,"given":"Tomohiko","family":"Moriyama","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Science, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"},{"name":"International Medical Department Kyushu University Hospital  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironobu","family":"Takedomi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Saga University  Saga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanae","family":"Tsuruoka","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Saga University  Saga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Ashizuka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Medicine Fukuoka University Faculty of Medicine  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noritaka","family":"Takatsu","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center Fukuoka University Chikushi Hospital  Chikushino Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Hisabe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Fukuoka University Chikushi Hospital  Chikushino Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Nozaka","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Matsuyama Red Cross Hospital  Matsuyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Kurahara","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Matsuyama Red Cross Hospital  Matsuyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Nakashima","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Faculty of Life Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoki","family":"Furuta","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Faculty of Life Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Morita","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine Kurume University School of Medicine  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kotaro","family":"Kuwaki","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine Kurume University School of Medicine  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuaki","family":"Nishimata","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sameshima Hospital  Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Kawano","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Steel Memorial Yawata Hospital  Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeo","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Steel Memorial Yawata Hospital  Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanami","family":"Ota","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Yamaguchi Red Cross Hospital  Yamaguchi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Harada","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Yamaguchi Red Cross Hospital  Yamaguchi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumihito","family":"Hirai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Medicine Fukuoka University Faculty of Medicine  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiro","family":"Torisu","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Science, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motohiro","family":"Esaki","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Saga University  Saga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"IBD\u2010Quality Team","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13247804"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.70073"},{"key":"e_1_2_9_4_1","article-title":"Real\u2010World Effectiveness and Safety of Upadacitinib in Crohn's Disease: A Multi\u2010Centre Study","author":"Devi J.","journal-title":"Clinical Gastroenterology and Hepatology"},{"issue":"1","key":"e_1_2_9_5_1","first-page":"190","article-title":"An Analysis of the Effectiveness and 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Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgh3.70291","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T13:49:17Z","timestamp":1761659357000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jgh3.70291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":10,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/jgh3.70291"],"URL":"https:\/\/doi.org\/10.1002\/jgh3.70291","archive":["Portico"],"relation":{},"ISSN":["2397-9070","2397-9070"],"issn-type":[{"value":"2397-9070","type":"print"},{"value":"2397-9070","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2025-05-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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