{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T01:20:30Z","timestamp":1785460830968,"version":"3.56.0"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Proton pump inhibitors (PPIs) remain the standard treatment option for erosive esophagitis (EE) but have notable limitations due to side effects associated with long\u2010term use. Tegoprazan, a novel potassium\u2010competitive acid suppressant (P\u2010CAB), may provide an alternative treatment option. In this study, we aim to evaluate the healing rates of EE using tegoprazan versus PPIs, along with their respective safety profiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A comprehensive literature search was conducted in PubMed, Embase, and\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      from inception to March 2025. Risk of bias was evaluated using the Cochrane RoB 2.0 tool. Pooled estimates were calculated using random\u2010effects models in Review Manager 5.4.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Three RCTs encompassing a total of 766 patients were included in the analysis. Tegoprazan demonstrated comparable healing rates to PPIs at both 4\u2009weeks (risk ratio [RR] 1.05; 95% confidence interval [CI]: 0.99\u20131.11;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.12) and 8\u2009weeks (RR 1.02; 95% CI: 0.98\u20131.06;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.35). Subgroup analyses by dose (50 and 100\u2009mg) showed no significant differences. While overall adverse event rates were similar between groups, the incidence of headache was numerically lower in the tegoprazan group (1.3% vs. 4.2%; RR\u2009=\u20090.40; 95% CI: 0.08\u20132.00;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.26), though this difference was not statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Tegoprazan shows comparable efficacy and safety to standard PPIs for treating EE. While healing rates were slightly higher, particularly with the 100\u2009mg dose, the differences were not statistically significant. Tegoprazan may be a suitable alternative for patients intolerant to PPIs, though larger, long\u2010term, multiethnic studies are warranted to confirm these findings and assess patient\u2010centered outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jgh3.70298","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T04:01:19Z","timestamp":1762833679000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Tegoprazan Versus Proton Pump Inhibitors for Erosive Esophagitis: A Meta\u2010Analysis of Noninferiority Randomized Controlled Trials"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9381-0106","authenticated-orcid":false,"given":"Muhammad Imaz","family":"Bhatti","sequence":"first","affiliation":[{"name":"King Edward Medical University  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7773-2605","authenticated-orcid":false,"given":"Muhammad","family":"Safiullah","sequence":"additional","affiliation":[{"name":"King Edward Medical University  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azka","family":"Ijaz","sequence":"additional","affiliation":[{"name":"King Edward Medical University  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9274-7421","authenticated-orcid":false,"given":"Qasim","family":"Mehmood","sequence":"additional","affiliation":[{"name":"King Edward Medical University  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishmal Fatima","family":"Shahid","sequence":"additional","affiliation":[{"name":"King Edward Medical University  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9480-7402","authenticated-orcid":false,"given":"Zahin","family":"Shahriar","sequence":"additional","affiliation":[{"name":"Dhaka Medical College Hospital  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,10]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"StatPearls","author":"Antunes 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