{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T15:08:17Z","timestamp":1771254497063,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2025,12]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Patterns of steroid use in inflammatory bowel disease remain poorly characterized in real\u2010world settings. Steroid exposure is associated with adverse effects and often indicates suboptimally controlled disease. Therefore, patterns and predictors of steroid use in a large inflammatory bowel disease cohort were examined.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Steroid exposure over a 3\u2010year window was explored. Use was classified by duration\u2014short (1\u201328\u2009days), moderate (29\u201356\u2009days), prolonged (>\u200956\u2009days), and recency (within last year, prior years or no exposure). Associations with demographic and disease\u2010related factors were assessed using multivariable logistic regression.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among 5436 people (median age 42\u2009years, IQR 32\u201356), 18.3% (\n n<\/jats:italic>\n \u2009=\u2009994) were steroid exposed. 57.6% had Crohn's disease and 50.2% were female. Crohn's disease was associated with lower odds of both\n prolonged<\/jats:italic>\n and\n recent<\/jats:italic>\n exposure compared to ulcerative colitis (AOR 0.72,\n p<\/jats:italic>\n \u2009=\u20090.001 and AOR 0.78,\n p<\/jats:italic>\n \u2009=\u20090.037, respectively). Females had a greater likelihood of both\n prolonged<\/jats:italic>\n and\n recent<\/jats:italic>\n exposure (AOR 1.22,\n p<\/jats:italic>\n \u2009=\u20090.048 and AOR 1.23,\n p<\/jats:italic>\n \u2009=\u20090.041, respectively). Young adults (20\u201329\u2009years) had higher odds of\n prolonged<\/jats:italic>\n and\n recent<\/jats:italic>\n use than those >\u200970\u2009years (AOR 6.59 and 9.12, respectively,\n p<\/jats:italic>\n \u2009<\u20090.001). Combination immunomodulator and advanced therapy use was associated with a higher likelihood of both prolonged and recent use compared to 5\u2010aminosalicylic acid therapy alone (AOR 4.01,\n p<\/jats:italic>\n \u2009=\u20090.002 and AOR 4.54,\n p<\/jats:italic>\n \u2009<\u20090.001). Age at diagnosis had a modest effect size (AOR 1.03,\n p<\/jats:italic>\n \u2009<\u20090.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Steroid use was modest, with over 80% unexposed over 3\u2009years. Proactive optimization of therapy, particularly in younger individuals and those with ulcerative colitis, may further reduce steroid exposure.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jgh3.70308","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T05:53:52Z","timestamp":1765259632000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Patterns and Predictors of Steroid Use in a Real\u2010World Inflammatory Bowel Disease Cohort"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2007-1726","authenticated-orcid":false,"given":"Rodger","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Liverpool Hospital Sydney New South Wales Australia"},{"name":"Crohn's Colitis Cure (CCCure) Sydney New South Wales Australia"},{"name":"Ingham Institute for Applied Medical Research Liverpool New South Wales Australia"},{"name":"South West Sydney Clinical Campuses, UNSW Medicine & Health UNSW Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Consuelo","family":"Rivas","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Liverpool Hospital Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6556-6708","authenticated-orcid":false,"given":"Wai Kin","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Liverpool Hospital Sydney New South Wales Australia"},{"name":"Crohn's Colitis Cure (CCCure) Sydney New South Wales Australia"},{"name":"Ingham Institute for Applied Medical Research Liverpool New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9e","family":"Deschenes","sequence":"additional","affiliation":[{"name":"Crohn's Colitis Cure (CCCure) Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Wilson","sequence":"additional","affiliation":[{"name":"Crohn's Colitis Cure (CCCure) Sydney New South Wales Australia"},{"name":"Department of Anaesthesia Lyell McEwin Hospital Adelaide South Australia Australia"},{"name":"SA Health Chief Medical Information Officer Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph L.","family":"Pipicella","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Liverpool Hospital Sydney New South Wales Australia"},{"name":"Crohn's Colitis Cure (CCCure) Sydney New South Wales Australia"},{"name":"Ingham Institute for Applied Medical Research Liverpool New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan J.","family":"Connor","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Liverpool Hospital Sydney New South Wales Australia"},{"name":"Crohn's Colitis Cure (CCCure) Sydney New South Wales Australia"},{"name":"Ingham Institute for Applied Medical Research Liverpool New South Wales Australia"},{"name":"South West Sydney Clinical Campuses, UNSW Medicine & Health UNSW Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane M.","family":"Andrews","sequence":"additional","affiliation":[{"name":"Crohn's Colitis Cure (CCCure) Sydney New South Wales Australia"},{"name":"IBD Service Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"Faculty of Health and Medical Sciences University of Adelaide Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Crohn's Colitis Cure (CCCure) Data Insights 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