{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T05:02:12Z","timestamp":1773032532662,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T00:00:00Z","timestamp":1771113600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Therapeutic drug monitoring (TDM) of non anti\u2010TNF biologics is not well established in clinical practice. We aimed to clarify the association between VTL and remission in our cohort of maintenance vedolizumab patients using objective markers of disease activity to see if this could aid in decision making.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cross\u2010sectional cohort study was performed on 83 consecutive moderate\u2013severe inflammatory bowel disease (IBD) patients. VTL measurement immediately prior to infusion was paired with clinical and objective markers of disease activity. Objective disease assessment was undertaken using fecal calprotectin, magnetic resonance imaging, intestinal ultrasound, or sigmoidoscopy\/colonoscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighty\u2010three patients on maintenance vedolizumab were evaluated (59% UC and 41% CD). The median age at diagnosis was 40\u2009years. Median trough vedolizumab levels were comparable in patients who achieved steroid\u2010free clinical remission (12.65\u2009\u03bcg\/mL vs. 8.89\u2009\u03bcg\/mL\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.771) or objective remission (15.22\u2009\u03bcg\/mL vs. 8.89\u2009\u03bcg\/mL\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.073) versus those who had not. Quartile analysis (Q1: &lt;\u20096.9\u2009\u03bcg\/mL, Q2: 6.9\u201312.2\u2009\u03bcg\/mL, Q3: 12.2\u201318.6\u2009\u03bcg\/mL, and Q4: &gt;\u200918\u2009ug\/mL) showed no difference between quartiles of vedolizumab levels and clinical or objective remission (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.65).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Vedolizumab trough levels were not associated with clinical or objective remission during maintenance therapy, and in our real\u2010world cohort, do not appear to be a clinically relevant target for TDM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jgh3.70320","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T04:40:06Z","timestamp":1771216806000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Therapeutic Drug Monitoring of Vedolizumab Levels During Maintenance in Inflammatory Bowel Disease (\n                    <scp>MOVE<\/scp>\n                    \u2010\n                    <scp>IBD<\/scp>\n                    )"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2811-7880","authenticated-orcid":false,"given":"Hayley","family":"Logan","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Sunshine Coast University Public Hospital  Sunshine Coast Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3136-8073","authenticated-orcid":false,"given":"Katherine","family":"Rimmer","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Sunshine Coast University Public Hospital  Sunshine Coast Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2863-0293","authenticated-orcid":false,"given":"James","family":"Doecke","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Sunshine Coast University Public Hospital  Sunshine Coast Queensland Australia"},{"name":"CSIRO Health and Biosecurity\/Australian E\u2010Health Research Centre, Royal Brisbane and Women's Hospital  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1367-6945","authenticated-orcid":false,"given":"Desmond","family":"Patrick","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Sunshine Coast University Public Hospital  Sunshine Coast Queensland Australia"},{"name":"Griffith University School of Medicine and Dentistry  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izy171"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.07.032"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14368"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1215734"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1215739"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izy272"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjz041"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2023.10.029"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/flgastro\u20102019\u2010101197"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15030972"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620\u2010019\u201005570\u20101"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjz029"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.04.040"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.16518"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.05.067"},{"key":"e_1_2_8_17_1","unstructured":"R\u2010Core team \u201cR. A Language and Environment for Statistical Computing R Foundation of Statistical Computing \u201d2024Vienna Austria."},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.1877"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14458"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.12.031"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.120"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16121629"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ygh2.444"}],"container-title":["JGH Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgh3.70320","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jgh3.70320","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgh3.70320","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:10:56Z","timestamp":1773029456000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jgh3.70320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/jgh3.70320"],"URL":"https:\/\/doi.org\/10.1002\/jgh3.70320","archive":["Portico"],"relation":{},"ISSN":["2397-9070","2397-9070"],"issn-type":[{"value":"2397-9070","type":"print"},{"value":"2397-9070","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2025-07-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70320"}}